Immunological lessons from CD28 deficiency in humans

被引：4
|
作者：
Wieland, Andreas [1 ,2 ]
Ahmed, Rafi [1 ,2 ]
机构：
[1] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA USA
[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA USA
来源：
CELL | 2021年 / 184卷 / 14期
关键词：
D O I：
10.1016/j.cell.2021.06.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Cell, Casanova and colleagues examine three family members with a mutation that results in deficiency of the T cell co-stimulatory molecule CD28. These patients exhibit clinical symptoms due to human papillomavirus-2 and -4 infections, show increased levels of Epstein-Barr virus and cytomegalovirus in the blood, and respond poorly to vaccines.
引用
收藏
页码：3595 / 3597
页数：3
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