Solid phase synthesis of fumitremorgin, verruculogen and tryprostatin analogs based on a cyclization/cleavage strategy

被引：60
|
作者：
van Loevezijn, A
van Maarseveen, JH
Stegman, K
Visser, GM
Koomen, GJ
机构：
[1] Univ Amsterdam, Inst Mol Chem, Organ Chem Lab, NL-1018 WS Amsterdam, Netherlands
[2] Solvay Pharmaceut Res Labs, NL-1380 DA Weesp, Netherlands
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 26期
关键词：
solid-phase synthesis; Pictet-Spengler reactions; amino acids and derivatives; coupling reagents;
D O I：
10.1016/S0040-4039(98)00931-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A solid phase synthesis towards structural analogs of fumitremorgins, verruculogens and tryprostatins using a cyclization/cleavage strategy was developed. To prove the general applicability of the route, a representative set of 42 single compounds (as diastereomeric mixtures) was prepared by parallel synthesis and analyzed with LC/MS. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4737 / 4740
页数：4
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