New cytotoxic sesterterpenes from the sponge Sarcotragus species

被引：45

作者：

Liu, YH

Bae, BH

Alam, N

Hong, J

Sim, CJ

Lee, CO

Im, KS

Jung, JH ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Korea Basic Sci Inst, Taejon, South Korea

[3] Hannam Univ, Dept Biol, Taejon, South Korea

[4] Korea Res Inst Chem Technol, Pharmaceut Screening Ctr, Taejon 305606, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 10期

关键词：

D O I：

10.1021/np0101494

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new (1-3, 5, and 7) and two known (4, 6) furanosesterterpene tetronic acids were isolated from the marine sponge Sarcotragus sp. by bioactivity-guided fractionation. These compounds showed cytotoxicity against a panel of five human tumor cell lines. The gross structures were established on the basis of NMR and MS analyses. The compounds showed interesting variations of geometry and absolute configuration.

引用

页码：1301 / 1304

页数：4

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