tert-Butyl 2-{[2,8-bis(trifluoromethyl)-quinolin-4-yl](hydroxy)methyl}-piperidine-1-carboxylate

被引：1
|
作者：
Goncalves, Raoni S. B. [2 ]
de Souza, Marcus V. N. [2 ]
Wardell, James L. [1 ]
Wardell, Solange M. S. V. [3 ]
Tiekink, Edward R. T. [4 ]
机构：
[1] Fundaco Oswaldo Cruz FIOCRUZ, Ctr Desenvolvimento Tecnol Saude CDTS, BR-21040900 Rio De Janeiro, Brazil
[2] Fundaco Oswaldo Cruz, Inst Tecnol Farmacos Farmanguinhos, BR-21041250 Rio De Janeiro, Brazil
[3] CHEMSOL, Aberdeen AB15 5NY, Scotland
[4] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷
关键词：
CRYSTAL-STRUCTURES; MEFLOQUINE; DESIGN;
D O I：
10.1107/S1600536811047726
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes being 41.64 (7)degrees. Helical supramolecular C(7) chains sustained by O-H center dot center dot center dot O hydrogen bonds propagating along the a-axis direction feature in the crystal packing. The F atoms of one of the CF3 groups are disordered over two orientations; the major component has a site occupancy of 0.824 (7).
引用
收藏
页码：O3315 / U163
页数：13
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