Highly Regioselective and Diastereoselective, One-Pot, Four-Component Synthesis of Novel Spiroindenoquinoxalineindolizidine Derivatives

被引：4

作者：

Moemeni, Mehdi ^{[1
]}

Arvinnezhad, Hamid ^{[1
]}

Samadi, Saadi ^{[1
]}

Salahi, Farbod ^{[1
]}

Jadidi, Khosrow ^{[1
]}

Notash, Behrouz ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Fac Sci, Dept Chem, GC, Tehran, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 03期

关键词：

1,3-DIPOLAR CYCLOADDITION REACTION; QUINOLIZIDINE ALKALOIDS; IONIC LIQUID; INDOLIZIDINE; PYRROLIZIDINES;

D O I：

10.1002/jhet.2121

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot, four-component procedure for the synthesis of novel spiroindenoquinoxalineindolizidines with high regioselectivity and diastereoselectivity from the 1,3-dipolar cycloaddition of azomethine ylides, generated from indenoquinoxalines and pipecolinic acid, and chalcones is described. The reaction occurs under reflux of ethanol as a green solvent and in the absence of any catalyst. The cycloadducts are obtained purely without future purification. The regiochemistry and stereochemistry of resultant cycloadducts have been determined by several 2D-NMR spectroscopic techniques and X-ray single crystal diffraction.

引用

页码：944 / 948

页数：5

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