Base-Promoted Multicomponent Reactions: A Synthesis of 2-Amino-1,3-selenazole Derivatives

被引：21
|
作者：
Liu, Hua-Wei [1 ,2 ]
Fang, Yi [1 ,2 ]
Wang, Shun-Yi [1 ,2 ]
Ji, Shun-Jun [1 ,2 ]
机构：
[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China
[2] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 05期
基金：
中国国家自然科学基金;
关键词：
ANTIOXIDANT ACTIVITY; ISOCYANIDES; SELENIUM; SELENAZOLES; ACIDS; ORGANOSELENIUM; SELENAZADIENES; INSERTION; AMINES; MIMICS;
D O I：
10.1021/acs.joc.9b03234
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New practical synthesis of 2-amino-1,3-selenazole with transition metal-free multicomponent reaction is reported here. A series of 2-amino-1,3-selenazole derivatives were afforded by the nucleophilic addition of amines to isoselenocyanate formed in situ, followed by Michael addition reaction and aromatization. The products were isolated from moderate to excellent yields.
引用
收藏
页码：3508 / 3516
页数：9
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