Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments

被引:0
|
作者
Tang, YP
Ma, YL
Chao, CC
Chen, KY
Lee, EHY [1 ]
机构
[1] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan
[2] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan
关键词
glial cell line-derived neurotrophic factor; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; (-)-deprenyl; GM1; ganglioside; melatonin; gene expression; striatum;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Glial cell line-derived neurotrophic factor (GDNF) has been shown to be a preferentially selective neurotrophic factor for dopamine (DA) neurons. In the present study, we have examined the distribution of GDNF mRNA expression in several major DA-containing cell body and terminal areas;and the regulation of GDNF mRNA expression upon various pharmacological treatments, Results indicated that there is a relatively higher GDNF mRNA level in neurons of the nigrostriatal and mesolimbic dopaminergic pathways. Upon chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment (30 mg/kg, i.p., for 7 days), DA level was decreased, whereas GDNF mRNA expression was increased in the striatum, suggesting that more GDNF is synthesized and expressed to cope with the neurotoxin insult, Furthermore, among several DA neuron protective and/or therapeutic agents examined, both intrastriatal injections of (-)-deprenyl (1.25 mu g and 2.5 mu g) and melatonin (30 mu g, 60 mu g, and 120 mu g) significantly enhanced GDNF mRNA expression in the striatum, whereas the same concentrations of (-)-deprenyl did not affect monoamine oxidase B (MAOB) activity, although it increased glutathione peroxidase (GPx) and/or superoxide dismutase (SOD) activities, Similarly, the same concentrations of melatonin did not alter SOD or GPx activities, except that the highest dose of melatonin (120 mu g) increased lipid peroxidation in the striatum, Conversely, GM1 ganglioside injection (45 mu g) lacked of an effect on GDNF mRNA expression. Together, these results suggest that both (-)-deprenyl and melatonin up-regulate GDNF gene expression at threshold doses lower than that needed for altering MAOB activity and/or the antioxidant enzyme systems, respectively. These results provide new information on the neuroprotective and therapeutic mechanisms of (-)-deprenyl and melatonin on DA neurons, (C) 1998 Wiley-Liss, Inc.
引用
收藏
页码:593 / 604
页数:12
相关论文
共 50 条
  • [31] The effect of exercise on glial cell line-derived neurotrophic factor (GDNF) expression in skeletal muscle
    Smith, Jennifer S.
    Wright, Rebecca E.
    Kinnell, Kyle R.
    Spitsbergen, John M.
    FASEB JOURNAL, 2007, 21 (05): : A577 - A577
  • [32] Expression and regulation of GFRα3, a glial cell line-derived neurotrophic factor family receptor
    Naveilhan, P
    Baudet, C
    Mikaels, Å
    Shen, LY
    Westphal, H
    Ernfors, P
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) : 1295 - 1300
  • [33] Differential expression of glial cell line-derived neurotrophic factor splice variants in the mouse brain
    Gu, Xiao-He
    Li, Heng
    Zhang, Lin
    He, Tao
    Chai, Xiang
    Wei, He
    Gao, Dian-Shuai
    NEURAL REGENERATION RESEARCH, 2020, 15 (02) : 270 - 276
  • [34] EXPRESSION OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR FAMILY IN PERIPHERAL NERVE SHEATH TUMORS
    Yamamoto, Tetsuji
    Akisue, Toshihiro
    Fujimoto, Takuya
    Kishimoto, Kenta
    Kawamoto, Teruya
    Hitora, Toshiaki
    Fujita, Takashi Marui Ikuo
    Kurosaka, Masahiro
    ANTICANCER RESEARCH, 2004, 24 (5D) : 3673 - 3674
  • [35] Focal expression of glial cell line-derived neurotrophic factor in developing mouse limb bud
    Wright, DE
    Snider, WD
    CELL AND TISSUE RESEARCH, 1996, 286 (02) : 209 - 217
  • [36] Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers
    Ito, Y
    Okada, Y
    Sato, M
    Sawai, H
    Funahashi, H
    Murase, T
    Hayakawa, T
    Manabe, T
    SURGERY, 2005, 138 (04) : 788 - 794
  • [37] Decreased expression of glial cell line-derived neurotrophic factor signaling in neuropathic pain state
    Sakai, A
    Nagano, M
    Yoshioka, K
    Suzuki, H
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 298P - 298P
  • [38] The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
    Yanran Zhang
    Haitang Jiang
    Yingying Yue
    Yingying Yin
    Yuqun Zhang
    Jinfeng Liang
    Shenghua Li
    Jun Wang
    Jianxin Lu
    Deqin Geng
    Aiqin Wu
    Yonggui Yuan
    Scientific Reports, 7
  • [39] Increased expression of glial cell line-derived neurotrophic factor mRNA in muscle biopsies from patients with amyotrophic lateral sclerosis
    Grundström, E
    Askmark, H
    Lindeberg, J
    Nygren, I
    Ebendal, T
    Aquilonius, SM
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 1999, 162 (02) : 169 - 173
  • [40] The protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
    Zhang, Yanran
    Jiang, Haitang
    Yue, Yingying
    Yin, Yingying
    Zhang, Yuqun
    Liang, Jinfeng
    Li, Shenghua
    Wang, Jun
    Lu, Jianxin
    Geng, Deqin
    Wu, Aiqin
    Yuan, Yonggui
    SCIENTIFIC REPORTS, 2017, 7