MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease

被引：3
|
作者：
Zhao, W. [1 ,2 ,4 ]
Wang, P. [1 ,2 ]
He, W. [5 ,6 ]
Tao, T. [1 ,2 ]
Li, H. [3 ]
Li, Y. [1 ,2 ]
Jiang, W. [3 ]
Sun, J. [1 ,2 ]
Ge, X. [8 ]
Chen, X. [1 ,2 ]
Zheng, Y. [1 ,2 ]
Wei, L. [1 ,2 ]
Chen, C. [1 ,2 ]
Wang, Y. [1 ,2 ]
Li, C. [1 ,2 ]
Chen, H. [7 ]
Yao, B. [4 ]
Tang, W. [3 ]
Zhu, M. [1 ,2 ]
机构：
[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Model Anim Res Ctr, Minist Educ MOE,Key Lab Model Anim Dis Study, Nanjing, Peoples R China
[2] Nanjing Univ, Sch Med, Nanjing, Peoples R China
[3] Nanjing Med Univ, Childrens Hosp, Dept Pediat Surg, Nanjing, Peoples R China
[4] Nanjing Univ, Affiliated Med Sch, Jinling Hosp, Reprod Med Ctr, Nanjing, Peoples R China
[5] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Peoples R China
[6] Soochow Univ, Cambridge Suda CAM SU Genom Resource Ctr, Suzhou, Peoples R China
[7] Nanjing Normal Univ, Coll Life Sci, Nanjing, Peoples R China
[8] Zhejiang Univ, Affiliated Med Coll, Sir Run Run Shaw Hosp, Dept Gen Surg, Hangzhou, Peoples R China
来源：
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2020年 / 9卷 / 02期
关键词：
SMOOTH-MUSCLE; CONTRACTILE ACTIVITY; CA2+ SENSITIVITY; PROTEINS;
D O I：
10.1016/j.jcmgh.2019.11.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
[No abstract available]
引用
收藏
页码：345 / +
页数：9
相关论文
共 50 条
  • [21] E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model
    Zhao, Ze
    Song, Xiaomeng
    Wang, Yimeng
    Yu, Lu
    Huang, Gan
    Li, Yiquan
    Zong, Runzhe
    Liu, Tengfei
    Ji, Qiuran
    Zheng, Yi
    Liu, Bingyu
    Zhu, Qingfen
    Chen, Lin
    Gao, Chengjiang
    Liu, Huiqing
    CELL DEATH AND DIFFERENTIATION, 2024, : 1410 - 1421
  • [22] The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia
    Lu, Xinxin
    Huang, Xinyue
    Xu, Haiqi
    Lu, Saien
    You, Shilong
    Xu, Jiaqi
    Zhan, Qianru
    Dong, Chao
    Zhang, Ning
    Zhang, Ying
    Cao, Liu
    Zhang, Xingang
    Zhang, Naijin
    Zhang, Lijun
    CELL DEATH DISCOVERY, 2022, 8 (01)
  • [23] The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia
    Xinxin Lu
    Xinyue Huang
    Haiqi Xu
    Saien Lu
    Shilong You
    Jiaqi Xu
    Qianru Zhan
    Chao Dong
    Ning Zhang
    Ying Zhang
    Liu Cao
    Xingang Zhang
    Naijin Zhang
    Lijun Zhang
    Cell Death Discovery, 8
  • [24] Carpaine alleviates tendinopathy in mice by promoting the ubiquitin-proteasomal degradation of p65 via targeting the E3 ubiquitin ligase LRSAM1
    Lin, Xuemei
    Tian, Xinggui
    Jiang, Huaji
    Li, Wenjun
    Wang, Chaomin
    Wu, Jianping
    Chen, Weidong
    Shi, Weizhe
    Tian, Qinyu
    Gong, Xiaoqian
    Zhou, Qinghe
    Xu, Hongwen
    Zwingenberger, Stefan
    PHYTOMEDICINE, 2024, 124
  • [25] Down-regulation of Intestinal Apical Calcium Entry Channel TRPV6 by Ubiquitin E3 Ligase Nedd4-2
    Zhang, Wei
    Na, Tao
    Wu, Guojin
    Jing, Haiyan
    Peng, Ji-Bin
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (47) : 36586 - 36596
  • [26] The E3 Ubiquitin-Ligase Bmi1/Ring1A Controls the Proteasomal Degradation of Top2α Cleavage Complex - A Potentially New Drug Target
    Alchanati, Iris
    Teicher, Carmit
    Cohen, Galit
    Shemesh, Vivian
    Barr, Haim M.
    Nakache, Philippe
    Ben-Avraham, Danny
    Idelevich, Anna
    Angel, Itzchak
    Livnah, Nurit
    Tuvia, Shmuel
    Reiss, Yuval
    Taglicht, Daniel
    Erez, Omri
    PLOS ONE, 2009, 4 (12):
  • [27] The E3 Ubiquitin Ligase Thyroid Hormone Receptor-interacting Protein 12 Targets Pancreas Transcription Factor 1a for Proteasomal Degradation
    Hanoun, Naima
    Fritsch, Samuel
    Gayet, Odile
    Gigoux, Veronique
    Cordelier, Pierre
    Dusetti, Nelson
    Torrisani, Jerome
    Dufresne, Marlene
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (51) : 35593 - 35604
  • [28] HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation
    Remoli, Anna Lisa
    Marsili, Giulia
    Perrotti, Edvige
    Acchioni, Chiara
    Sgarbanti, Marco
    Borsetti, Alessandra
    Hiscott, John
    Battistini, Angela
    MBIO, 2016, 7 (05):
  • [29] E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation
    Liu, Liu
    Yu, Le
    Zeng, Cheng
    Long, Hua
    Duan, Guangjie
    Yin, Guobing
    Dai, Xiaotian
    Lin, Zhenghong
    MOLECULAR AND CELLULAR BIOLOGY, 2020, 40 (07)
  • [30] The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
    Lu, ZM
    Xu, SC
    Joazeiro, C
    Cobb, MH
    Hunter, T
    MOLECULAR CELL, 2002, 9 (05) : 945 - 956
12345