Epigenetic clocks for gestational age: statistical and study design considerations

被引：23

作者：

Simpkin, Andrew J. ^{[1
]}

Suderman, Matthew ^{[1
]}

Howe, Laura D. ^{[1
]}

机构：

[1] Univ Bristol, Populat Hlth Sci, Bristol Med Sch, MRC Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England

来源：

CLINICAL EPIGENETICS | 2017年 / 9卷

基金：

英国惠康基金; 英国经济与社会研究理事会; 英国医学研究理事会;

关键词：

Prediction; DNA methylation; Gestational age at delivery; Epigenetic clock; BIRTH;

D O I：

10.1186/s13148-017-0402-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methylation data.

引用

页数：2

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