Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography

被引：16
|
作者：
Ishiwata, K [1 ]
Tsukada, H
Kubota, K
Nariai, T
Harada, N
Kawamura, K
Kimura, Y
Oda, K
Iwata, R
Ishii, K
机构：
[1] Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Itabashi Ku, Tokyo 1730022, Japan
[2] Hamamatsu Photon KK, Cent Res Lab, Hamakita 4348601, Japan
[3] Int Med Ctr Japan, Div Nucl Med, Dept Radiol, Shinjuku Ku, Tokyo 1628655, Japan
[4] Tokyo Med & Dent Univ, Dept Neurosurg, Bunkyo Ku, Tokyo 1138519, Japan
[5] SHI Accelerator Serv Ltd, Shinagawa Ku, Tokyo 1418686, Japan
[6] Tohoku Univ, CYRIC, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2005年 / 32卷 / 03期
基金：
日本学术振兴会;
关键词：
O-[C-11]methyl-L-tyrosine; tumor imaging; positron emission tomography;
D O I：
10.1016/j.nucmedbio.2004.11.005
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
We performed preclinical and clinical studies of O-[C-11]methyl-L-tyrosine, a potential tracer for imaging amino acid transport Of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[C-11]methyl-L-tyrosine and the acute toxicity and mutagenicity of O-methyl-L-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[C-11]methyl-L-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[C-11]methyl-L-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：253 / 262
页数：10
相关论文
共 50 条
  • [21] Imaging epileptogenic tubers in children with tuberous sclerosis complex using α-[11C]methyl-L-tryptophan positron emission tomography
    Chugani, DC
    Chugani, HT
    Muzik, O
    Shah, JR
    Shah, AK
    Canady, A
    Mangner, TJ
    Chakraborty, PK
    ANNALS OF NEUROLOGY, 1998, 44 (06) : 858 - 866
  • [22] Magnetic resonance imaging and [11C]methyl-L-methionine positron emission tomography of fibrous dysplasia -: Two case reports
    Tsuyuguchi, N
    Ohata, K
    Morino, M
    Takami, T
    Goto, T
    Nishio, A
    Hara, M
    Sunada, I
    NEUROLOGIA MEDICO-CHIRURGICA, 2002, 42 (08) : 341 - 345
  • [23] 11C=O bonds made easily for positron emission tomography radiopharmaceuticals
    Rotstein, Benjamin H.
    Liang, Steven H.
    Placzek, Michael S.
    Hooker, Jacob M.
    Gee, Antony D.
    Dolle, Frederic
    Wilson, Alan A.
    Vasdev, Neil
    CHEMICAL SOCIETY REVIEWS, 2016, 45 (17) : 4708 - 4726
  • [24] α[11C]methyl-L-tryptophan positron emission tomography scanning in 176 patients with intractable epilepsy
    Juhász, C
    Chugani, DC
    Asano, E
    Shah, A
    Shah, J
    Muzik, O
    Sood, S
    Chugani, HT
    ANNALS OF NEUROLOGY, 2002, 52 (03) : S118 - S118
  • [25] Evaluation of [11C]UCB-A positron emission tomography in human brains
    Xiong, Mengfei
    Lubberink, Mark
    Appel, Lieuwe
    Fang, Xiaotian Tsong
    Danfors, Torsten
    Kumlien, Eva
    Antoni, Gunnar
    EJNMMI RESEARCH, 2024, 14 (01):
  • [26] Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB
    S. Houle
    N. Ginovart
    D. Hussey
    J.H. Meyer
    A.A. Wilson
    European Journal of Nuclear Medicine, 2000, 27 : 1719 - 1722
  • [27] Imaging the serotonin transporter with positron emission tomography:: initial human studies with [11C]DAPP and [11C]DASB
    Houle, S
    Ginovart, N
    Hussey, D
    Meyer, JH
    Wilson, AA
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (11) : 1719 - 1722
  • [28] Positron emission tomography with [11C]-acetate for evaluation of myocardial oxidative metabolism. Clinical use
    Litvinova, I.S.
    Litvinov, M.M.
    Rozhkova, G.G.
    Leont'eva, I.V.
    Sebeleva, I.A.
    Tumanyan, M.R.
    Koledinskij, D.G.
    Sukhorukov, V.S.
    Meditsinskaya Radiologiya I Radiatsionnaya Bezopasnost', 2001, 46 (04): : 51 - 60
  • [29] A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C] Dehydropravastatin in Humans Using Positron Emission Tomography
    Kaneko, Ken-Ichi
    Tanaka, Masaaki
    Ishii, Akira
    Katayama, Yumiko
    Nakaoka, Takayoshi
    Irie, Satsuki
    Kawahata, Hideki
    Yamanaga, Takashi
    Wada, Yasuhiro
    Miyake, Takeshi
    Toshimoto, Kota
    Maeda, Kazuya
    Cui, Yilong
    Enomoto, Masaru
    Kawamura, Etsushi
    Kawada, Norifumi
    Kawabe, Joji
    Shiomi, Susumu
    Kusuhara, Hiroyuki
    Sugiyama, Yuichi
    Watanabe, Yasuyoshi
    DRUG METABOLISM AND DISPOSITION, 2018, 46 (05) : 719 - 728
  • [30] Imaging of bladder cancer using 11C choline positron emission tomography (PET).
    Jong, IJ
    Que, TH
    Pruim, J
    Zweers, HM
    Mensink, HJ
    Vaalburg, W
    JOURNAL OF NUCLEAR MEDICINE, 2000, 41 (05) : 74P - 74P
12345