Synthesis and biological activity of N-acylated ornithine analogues of daptomycin

被引:44
|
作者
Hill, J [1 ]
Siedlecki, J [1 ]
Parr, I [1 ]
Morytko, M [1 ]
Yu, X [1 ]
Zhang, YZ [1 ]
Silverman, J [1 ]
Controneo, N [1 ]
Laganas, V [1 ]
Li, TC [1 ]
Lai, JJ [1 ]
Keith, D [1 ]
Shimer, G [1 ]
Finn, J [1 ]
机构
[1] Cubist Pharmaceut Inc, Lexington, MA 02421 USA
关键词
D O I
10.1016/j.bmcl.2003.07.019
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4187 / 4191
页数:5
相关论文
共 50 条
  • [1] Synthesis of fused bicyclic thioglycosides of N-acylated glucosamine as analogues of mycothiol
    Slattegard, Rikard
    Gammon, David W.
    Oscarson, Stefan
    [J]. CARBOHYDRATE RESEARCH, 2007, 342 (12-13) : 1943 - 1946
  • [2] First synthesis of N-acylated photoactivatable analogues of glutathione bearing an aryl azide moiety
    Bernardi, Dan
    Ba, Lalla Aicha
    Kirsch, Gilbert
    [J]. SYNTHESIS-STUTTGART, 2007, 1 (01): : 140 - 144
  • [3] PHOTOSTABILIZING ACTIVITY OF N-ACYLATED HINDERED AMINE
    KURUMADA, T
    OHSAWA, H
    FUJITA, T
    TODA, T
    YOSHIOKA, T
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1985, 23 (11) : 2747 - 2756
  • [4] A novel approach for the solid-phase synthesis of substituted cyclic guanidines, their respective bis analogues, and N-acylated guanidines from N-acylated amino acid amides
    Acharya, AN
    Ostresh, JM
    Houghten, RA
    [J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (06): : 578 - 589
  • [5] PEPTIDE SYNTHESIS VIA N-ACYLATED AZIRIDINONE .2. REACTION OF N-ACYLATED AZIRIDINONE AND ITS USE IN PEPTIDE SYNTHESIS
    MIYOSHI, M
    [J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1973, 46 (05) : 1489 - 1496
  • [6] N-Acylated Ciprofloxacin Derivatives: Synthesis and In Vitro Biological Evaluation as Antibacterial and Anticancer Agents
    Struga, Marta
    Roszkowski, Piotr
    Bielenica, Anna
    Otto-Slusarczyk, Dagmara
    Stepienn, Karolina
    Stefanska, Joanna
    Zabost, Anna
    Augustynowicz-Kopec, Ewa
    Kolinski, Michal
    Kmiecik, Sebastian
    Myslovska, Alina
    Wrzosek, Malgorzata
    [J]. ACS OMEGA, 2023, 8 (21): : 18663 - 18684
  • [7] Synthesis of N-acylated dialkoxyphosphorylalkyl esters of imidic acids
    Shishkin, VE
    Mednikov, EV
    Zubareva, EV
    No, BI
    [J]. ZHURNAL OBSHCHEI KHIMII, 1996, 66 (07): : 1222 - 1223
  • [8] N-ACYLATED GLYCEROPHOSPHOLIPIDS AND THEIR DERIVATIVES
    SCHMID, HHO
    SCHMID, PC
    NATARAJAN, V
    [J]. PROGRESS IN LIPID RESEARCH, 1990, 29 (01) : 1 - 43
  • [9] Comparison of the biological activity of synthetic N-acylated asparagine or serine linked monosaccharide lipid a analogs
    Shimizu, T
    Iwamoto, Y
    Yanagihara, Y
    Ryoyama, K
    Suhara, Y
    Ikeda, K
    Achiwa, K
    [J]. IMMUNOBIOLOGY, 1996, 196 (04) : 321 - 331
  • [10] Synthesis and activity of N-acylated azacyclic urea inhibitors of HIV-1 protease
    Zhao, C
    Sham, H
    Lin, S
    Stewart, K
    Betebenner, D
    Rosenbrook, W
    Herrin, T
    Madigan, D
    Saldivar, A
    Wideburg, N
    Vasavanonda, S
    Robins, T
    McDonald, E
    Marsh, K
    Park, C
    Li, L
    Kempf, D
    Plattner, J
    Norbeck, D
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 211 : 162 - MEDI