Tolerance and pharmacokinetics of pitolisant (Wakix®), a histamine H3 antagonist, in 24 narcoleptic children

被引：0
|
作者：
Lecendreux, M. [1 ]
Plazzi, G. [2 ]
Franco, P. [3 ]
Robert, P. [4 ]
Duvauchelle, T. [5 ]
Lecomte, J. -M. [5 ]
机构：
[1] Robert Debre Univ Hosp, Clin Invest Ctr, Paris, France
[2] Univ Bologna, Dipartimento Sci Biomed & Neuromotorie, Alma Mater Studiorum, Bologna, Italy
[3] Univ Hosp, Pediat Sleep Dept, Lyon, France
[4] Bioprojet Biotech, St Gregoire, France
[5] Bioprojet, Paris, France
来源：
JOURNAL OF SLEEP RESEARCH | 2016年 / 25卷
关键词：
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
P442
引用
收藏
页码：230 / 231
页数：2
相关论文
共 50 条
  • [31] CLINICAL TRIALS WITH PITOLISANT (WAKIX®) A WAKE-PROMOTING H3-RECEPTOR INVERSE AGONIST
    Schwartz, J-C
    INFLAMMATION RESEARCH, 2014, 63 : S8 - S8
  • [32] Influence of bulky substituents on histamine H3 receptor agonist/antagonist properties
    Sasse, A
    Ligneau, X
    Rouleau, A
    Elz, S
    Ganellin, CR
    Arrang, JM
    Schwartz, JC
    Schunack, W
    Stark, H
    JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (18) : 4000 - 4010
  • [33] Protective effect of histamine H3 receptor antagonist on cerebral ischemic injury
    Hu, Wei-wei
    Zhang, Xiang-nan
    Yan, Hai-jing
    Ohtsu, Hiroshi
    Han, Feng
    Chen, Zhong
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015, 128 (03) : S31 - S31
  • [34] Different antagonist binding properties of human and rat histamine H3 receptors
    Stark, H
    Sippl, W
    Ligneau, X
    Arrang, JM
    Ganellin, CR
    Schwartz, JC
    Schunack, W
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (07) : 951 - 954
  • [35] Drug-drug interaction potential and clinical pharmacokinetics of enerisant, a novel potent and selective histamine H3 receptor antagonist
    Terasaka, Shuichi
    Hachiuma, Kenji
    Mano, Yoko
    Onishi, Koichi
    Kitajima, Iwao
    Nishino, Izumi
    Endo, Hiromi
    XENOBIOTICA, 2021, 51 (07) : 786 - 795
  • [36] Safety, tolerability and pharmacokinetics of the histamine H3 receptor antagonist, ABT-288, in healthy young adults and elderly volunteers
    Othman, Ahmed A.
    Haig, George
    Florian, Hana
    Locke, Charles
    Zhang, Jun
    Dutta, Sandeep
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 75 (05) : 1299 - 1311
  • [37] Pitolisant, an Inverse Agonist of the Histamine H3 Receptor: An Alternative Stimulant for Narcolepsy-Cataplexy in Teenagers With Refractory Sleepiness
    Inocente, Clara
    Arnulf, Isabelle
    Bastuji, Helene
    Thibault-Stoll, Anne
    Raoux, Aude
    Reimao, Rubens
    Lin, Jian-Sheng
    Franco, Patricia
    CLINICAL NEUROPHARMACOLOGY, 2012, 35 (02) : 55 - 60
  • [38] Synergy of antiseizure and anxiolytic action of rapamycin and histamine H3 inverse agonist pitolisant on the PTZ-kindled seizures
    Poshyvak, O. B.
    Pinyazhko, O. R.
    Pervak, Mykhailo
    Yehorenko, O. S.
    Prybolovets, Kseniia
    Godlevsky, L. S.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
  • [39] Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness
    Inocente, C. O.
    Arnulf, I.
    Bastuji, H.
    Thibault-Stoll, A.
    Raoux, A.
    Reimao, R.
    Lin, J-S
    Franco, P.
    JOURNAL OF SLEEP RESEARCH, 2012, 21 : 317 - 317
  • [40] Effects of pitolisant, a histamine H3 inverse agonist, in drug-resistant idiopathic and symptomatic hypersomnia: a chart review
    Leu-Semenescu, Smaranda
    Nittur, Nandy
    Golmard, Jean-Louis
    Arnulf, Isabelle
    SLEEP MEDICINE, 2014, 15 (06) : 681 - 687
12345