Trifluoroacetylation in Organic Synthesis: Reagents, Developments and Applications in the Construction of Trifluoromethylated Compounds

被引：25

作者：

Lopez, Simon E. ^{[1
]}

Restrepo, Jelem ^{[1
]}

Salazar, Jose ^{[1
]}

机构：

[1] Univ Simon Bolivar, Dept Quim, Lab Quim Med & Heterociclos, Caracas 1080A, Venezuela

来源：

CURRENT ORGANIC SYNTHESIS | 2010年 / 7卷 / 05期

关键词：

Trifluoroacetylation; trifluoroacetylation reagents; trifluoromethyl heterocycles; trifluoromethylated compounds; trifluoroacetyl group; ONE-POT SYNTHESIS; MICROWAVE-PROMOTED TRIFLUOROACETYLATION; N-TRIFLUORACETYL-AMINOSAUREN; CARBOXYLIC-ACIDS; AMINO-ACIDS; PEPTIDE-SYNTHESIS; SELECTIVE TRIFLUOROACETYLATION; ETHYL TRIFLUOROACETATE; CONVENIENT SYNTHESIS; ACYLATING REAGENTS;

D O I：

10.2174/157017910792246126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review covers the trifluoroacetylation reaction in organic synthesis and its importance for the construction of trifluoromethylated compounds. Developed reagents for trifluoroacetylation are described, as well as their characteristics and preparation, giving emphasis on their applications and limitations in organic synthesis. Trifluoroacetylation, although commonly employed for the protection of functional groups (amines, alcohols, thiols), may be a useful tool for the further introduction of a trifluoromethyl group into an organic molecule. Its application, mainly in the synthesis of trifluoromethyl-heterocycles such as benzothiadiazines, pyrazoles, benzodiazepines, thieno-thiazines, isoxazoles and pyrimidines, is also covered.

引用

页码：414 / 432

页数：19

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