Zinc transporters maintain longevity by influencing insulin/IGF-1 activity in Caenorhabditis elegans

被引：6
|
作者：
Novakovic, Stevan [1 ,2 ]
Molesworth, Luke W. [3 ]
Gourley, Taylin E. [3 ]
Boag, Peter R. [1 ,2 ]
Davis, Gregory M. [3 ]
机构：
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia
[2] Monash Biomed Discovery Inst, Dev & Stem Cells Program, Clayton, Vic, Australia
[3] Federat Univ, Sch Hlth & Life Sci, Churchill, Vic, Australia
来源：
FEBS LETTERS | 2020年 / 594卷 / 09期
关键词：
Caenorhabditis elegans; zinc; development; insulin signalling; transcription factor; C-ELEGANS; LIFE-SPAN; DAF-16; PROTEIN; FAMILY; ROLES; SIGNALS; SKN-1;
D O I：
10.1002/1873-3468.13725
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/IGF-1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transport proteins (ZIPT in C. elegans). This study investigated the role of the zipt family of genes and showed that depletion of individual zipt genes results in a decreased lifespan. Moreover, zipt-16 and zipt-17 mutants synthetically interact with the insulin/IGF cofactors daf-16 and skn-1, and cause abnormal localisation of DAF-16. This study suggests that the zipt family of genes are required for maintaining normal lifespan through influencing the insulin/IGF-1 pathway.
引用
收藏
页码：1424 / 1432
页数：9
相关论文
共 50 条
  • [31] Chronic Exposure to Perfluorooctane Sulfonate Reduces Lifespan of Caenorhabditis elegans Through Insulin/IGF-1 Signaling
    Tiantian Xu
    Ping Li
    Siyu Wu
    Dan Li
    Jingxuan Wu
    Kathleen M. Raley-Susman
    Defu He
    Bulletin of Environmental Contamination and Toxicology, 2016, 97 : 119 - 123
  • [32] Chronic Exposure to Perfluorooctane Sulfonate Reduces Lifespan of Caenorhabditis elegans Through Insulin/IGF-1 Signaling
    Xu, Tiantian
    Li, Ping
    Wu, Siyu
    Li, Dan
    Wu, Jingxuan
    Raley-Susman, Kathleen M.
    He, Defu
    BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2016, 97 (01) : 119 - 123
  • [33] Genetic variation in insulin/IGF-1 signaling pathways and longevity
    Ziv, Elad
    Hu, Donglei
    AGEING RESEARCH REVIEWS, 2011, 10 (02) : 201 - 204
  • [34] Human insulin/IGF-1 and familial longevity at middle age
    Rozing, Maarten P.
    Westendorp, Rudi G. J.
    Frolich, Marijke
    de Craen, Anton J. M.
    Beekman, Marian
    Heijmans, Bastiaan T.
    Mooijaart, Simon P.
    Blauw, Gerard-Jan
    Slagboom, P. Eline
    van Heemst, Diana
    AGING-US, 2009, 1 (08): : 714 - 722
  • [35] Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
    Chen, Haiyan
    Li, Rongji
    Zhao, Feng
    Luan, Li
    Han, Tiantian
    Li, Zhong
    FRONTIERS IN NUTRITION, 2022, 9
  • [36] Cynaroside extends lifespan and improves the neurondegeneration diseases via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
    Xiao, Yi
    Zhang, Yan
    Li, Linlu
    Jiang, Nian
    Yu, Changyan
    Li, Sanhua
    Zhu, Xinting
    Liu, Fang
    Liu, Yun
    ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2024, 122
  • [37] Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 receptor
    Patel, Dhaval S.
    Garza-Garcia, Acely
    Nanji, Manoj
    McElwee, Joshua J.
    Ackerman, Daniel
    Driscoll, Paul C.
    Gems, David
    GENETICS, 2008, 178 (02) : 931 - 946
  • [38] LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans
    Nanji, M
    Hopper, NA
    Gems, D
    AGING CELL, 2005, 4 (05) : 235 - 245
  • [39] Glucose Induces Sensitivity to Oxygen Deprivation and Modulates Insulin/IGF-1 Signaling and Lipid Biosynthesis in Caenorhabditis elegans
    Garcia, Anastacia M.
    Ladage, Mary L.
    Dumesnil, Dennis R.
    Zaman, Khadiza
    Shulaev, Vladimir
    Azad, Rajeev K.
    Padilla, Pamela A.
    GENETICS, 2015, 200 (01) : 167 - U353
  • [40] The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster
    Altintas, Ozlem
    Park, Sangsoon
    Lee, Seung-Jae V.
    BMB REPORTS, 2016, 49 (02) : 81 - 92
12345