Metalloproteinases and angiogenesis

被引：4
|
作者：
Gabison, EE
Hoang-Xuan, T
Mauviel, A
Menashi, S
机构：
[1] Hop St Louis, INSERM, Inst Rech Peau, Unite 532, F-75010 Paris, France
[2] Hop Bichat Claude Bernard, Fdn Ophtalmol, Serv Ophtalmol, F-75019 Paris, France
来源：
PATHOLOGIE BIOLOGIE | 2003年 / 51卷 / 03期
关键词：
angiogenesis; metalloproteinases; endothelial cells;
D O I：
10.1016/S0369-8114(03)00018-X
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Metalloproteinases (MMPs) are essential regulators during various phases of the angiogenic process. These include the degradation of the basement membrane and the extracellular matrix, the mobilisation and activation of growth factors and the production of fragments with pro-or anti-angiogenic activity. In addition to their role in migration and invasion, MMPs can influence endothelial cell proliferation and survival by modifying the balance between angiogenic and anti-angiogenic molecules. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：161 / 166
页数：6
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