Ga-68-PSMA PET/CT was performed in a 75-year-old man with newly diagnosed prostate cancer because of an equivocal lesion in the spine both on Tc-99m-bone-SPECT/CT and MRI. Because of increased PSMA activity on PET/CT, the bone lesion was interpreted as metastasis from prostate cancer. Later, the patient was diagnosed as having monoclonal gammopathy of unknown significance. A biopsy was performed, and histological examination revealed multiple myeloma with PSMA expression in the neovessels but no metastatic prostate cancer cells. The patient was downstaged, and the treatment was changed accordingly. This case illustrates the importance of biopsies from PSMA PET-positive lesions.
机构:
Department of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, UtrechtDepartment of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, Utrecht
de Keizer B.
Krijger G.C.
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Department of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, UtrechtDepartment of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, Utrecht
Krijger G.C.
Ververs F.T.
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Department of clinical pharmacy, UMC Utrecht, UtrechtDepartment of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, Utrecht
Ververs F.T.
van Es R.J.J.
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Department of head and neck surgical oncology, UMC Utrecht, UtrechtDepartment of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, Utrecht
van Es R.J.J.
de Bree R.
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Department of head and neck surgical oncology, UMC Utrecht, UtrechtDepartment of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, Utrecht
de Bree R.
Willems S.
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Department of pathology, UMC Utrecht, UtrechtDepartment of nuclear medicine and radiology, UMC Utrecht, room E01.132, Heidelberglaan 100, Utrecht
机构:
Nepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, AustraliaNepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia
Saad, Jeremy
Shanmugasundaram, Ramesh
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Nepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia
Univ Sydney, Fac Med & Hlth, Sydney, NSW, AustraliaNepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia
Shanmugasundaram, Ramesh
Wong, Veronica
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Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia
Nepean Hosp, Dept Nucl Med, Kingswood, NSW, AustraliaNepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia
Wong, Veronica
Le, Ken
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Nepean Hosp, Dept Nucl Med, Kingswood, NSW, AustraliaNepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia
Le, Ken
Arianayagam, Mohan
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Nepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, AustraliaNepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia
Arianayagam, Mohan
Roberts, Matthew J.
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Nepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia
Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia
Univ Queensland, Ctr Clin Res, Brisbane, Qld, AustraliaNepean Hosp, Nepean Urol Res Grp, Kingswood, NSW, Australia