Reassortment between seasonal and swine-origin H1N1 influenza viruses generates viruses with enhanced growth capability in cell culture

被引：22

作者：

Octaviani, Cassio Pontes ^{[1
]}

Li, Chengjun ^{[4
]}

Noda, Takeshi ^{[2
]}

Kawaoka, Yoshihiro ^{[1
,2
,3
,4
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol,Minato Ku, Tokyo 1088639, Japan

[2] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Special Pathogens,Minato Ku, Tokyo 1088639, Japan

[3] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Kawaguchi, Saitama 3320012, Japan

[4] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Influenza Res Inst, Madison, WI 53711 USA

来源：

VIRUS RESEARCH | 2011年 / 156卷 / 1-2期

基金：

日本科学技术振兴机构;

关键词：

Influenza virus; Swine-origin; Pandemic; Seasonal; Reassortment; A VIRUS; PANDEMIC INFLUENZA; VIRULENCE; PROTEIN; TAIL;

D O I：

10.1016/j.virusres.2010.12.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One year after the emergence of the 2009 influenza (H1N1) pandemic, most cases have been relatively mild; however, the possibility of enhanced viral growth ability by reassortment with seasonal viruses cannot be overlooked. Here, we show that reassortant viruses containing a seasonal H1 HA and swine-origin NA and M genes have enhanced virus growth over their wild-type parental viruses. The emergence of such viruses in nature could, therefore, represent a threat. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：147 / 150

页数：4

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