It is generally believed that pigs can serve as an intermediate host for the transmission of avian influenza viruses to humans or as mixing vessels for the generation of avian-human reassortant viruses. Here we describe the antigenic and genetic characterization of two influenza A (H1N1) viruses, which were isolated in The Netherlands from two patients who suffered from pneumonia. Both viruses proved to be antigenically and genetically similar to avian-like swine influenza A (H1N1) viruses which currently circulate in European pigs. It is concluded that European swine H1N1 viruses can infect humans directly, causing serious disease without the need for any reassortment event, (C) 2001 Academic Press.
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Winthrop Univ Hosp, Div Infect Dis, Long Isl City, NY 11501 USA
SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USAWinthrop Univ Hosp, Div Infect Dis, Long Isl City, NY 11501 USA
机构:
Univ Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 8820808, ChileUniv Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 8820808, Chile
Tapia, Rodrigo
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Torremorell, Montserrat
Culhane, Marie
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Univ Minnesota, Coll Vet Med, Dept Vet Populat Med, St Paul, MN 55108 USAUniv Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 8820808, Chile
Culhane, Marie
Medina, Rafael A.
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Pontificia Univ Catolica Chile, Dept Enfermedades Infecciosas & Inmunol Pediat, Escuela Med, Santiago 8330024, Chile
Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USAUniv Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 8820808, Chile
Medina, Rafael A.
Neira, Victor
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Univ Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 8820808, ChileUniv Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 8820808, Chile
机构:
China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Song, Yafen
Zhang, Yong
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Zhang, Yong
Zhang, Bing
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Zhang, Bing
Chen, Ling
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Chen, Ling
Zhang, Min
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Zhang, Min
Wang, Jingwen
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Wang, Jingwen
Jiang, Ying
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Jiang, Ying
Yang, Chenghuai
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China
Yang, Chenghuai
Jiang, Taozhen
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China Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R ChinaChina Inst Vet Drug Control, Dept Vet Culture Collect, 8 Nandajie, Beijing 100081, Peoples R China