Antigenic and genetic characterization of swine influenza A (H1N1) viruses isolated from pneumonia patients in the Netherlands

被引：50
|
作者：
Rimmelzwaan, GF
de Jong, JC
Bestebroer, TM
van Loon, AM
Claas, ECJ
Fouchier, RAM
Osterhaus, ADM
机构：
[1] Erasmus Med Ctr Rotterdam, Inst Virol, Natl Influenza Ctr, NL-3000 DR Rotterdam, Netherlands
[2] Erasmus Med Ctr Rotterdam, WHO, Natl Influenza Ctr, NL-3000 DR Rotterdam, Netherlands
[3] Acad Hosp Utrecht, Dept Clin Microbiol, Utrecht, Netherlands
来源：
VIROLOGY | 2001年 / 282卷 / 02期
关键词：
D O I：
10.1006/viro.2000.0810
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
It is generally believed that pigs can serve as an intermediate host for the transmission of avian influenza viruses to humans or as mixing vessels for the generation of avian-human reassortant viruses. Here we describe the antigenic and genetic characterization of two influenza A (H1N1) viruses, which were isolated in The Netherlands from two patients who suffered from pneumonia. Both viruses proved to be antigenically and genetically similar to avian-like swine influenza A (H1N1) viruses which currently circulate in European pigs. It is concluded that European swine H1N1 viruses can infect humans directly, causing serious disease without the need for any reassortment event, (C) 2001 Academic Press.
引用
收藏
页码：301 / 306
页数：6
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