For better or for worse: the role of Pim oncogenes in tumorigenesis

被引：399

作者：

Nawijn, Martijn C. ^{[1
,2
]}

Alendar, Andrej ^{[1
]}

Berns, Anton ^{[1
]}

机构：

[1] Netherlands Canc Inst, Dept Mol Genet, NL-1066 CX Amsterdam, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Lab Allergol & Pulm Dis, NL-9713 GZ Groningen, Netherlands

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 01期

关键词：

ABERRANT SOMATIC HYPERMUTATION; B-CELL LYMPHOMA; SERINE/THREONINE KINASE-ACTIVITY; CHRONIC LYMPHOCYTIC-LEUKEMIA; HUMAN PANCREATIC-CANCER; E-MU-MYC; C-MYC; GENE-EXPRESSION; PROTOONCOGENE PIM-1; UP-REGULATION;

D O I：

10.1038/nrc2986

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and epithelial origin. Pim genes encode serine/threonine kinases that have been shown to counteract the increased sensitivity to apoptosis induction that is associated with MYC-driven tumorigenesis. Recently, considerable progress has been made in characterizing the pathways of PIM-mediated survival signalling. Given the unique structure of their active site and the minimal phenotype of mice mutant for all Pim family members, these oncogenes might be promising targets for highly specific and selective drugs with favourable toxicity profiles. In this Review, we discuss the physiological functions and oncogenic activities of Pim kinases.

引用

页码：23 / 34

页数：12

共 50 条

[21] FOR BETTER OR WORSE
KENNEDY, G
COLUMBIA JOURNALISM REVIEW, 1977, 16 (01) : 72 - 72
[22] FOR BETTER OR WORSE
FINCHER, C
RESEARCH IN HIGHER EDUCATION, 1985, 23 (02) : 219 - 223
[23] For better or worse
Holdstock, Douglas
NEW SCIENTIST, 2008, 199 (2663) : 21 - 21
[24] For better or worse?
Mew, J
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 1998, 113 (04) : 33A - 33A
[25] For Better and for Worse
Coe, Clellan
AMERICAN SCHOLAR, 2015, 84 (01): : 61 - 69
[26] For Better or for Worse
Sandesara, Anand
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2022, 63 (06) : E773 - E774
[27] For better or worse?
Rauch, J
NEW REPUBLIC, 1996, 214 (19) : 18 - +
[28] For better or worse
Nature, 2012, 484 : 415 - 415
[29] FOR BETTER OR WORSE
LEGRAND, J
NEW STATESMAN & SOCIETY, 1993, 6 (279): : 22 - 23
[30] WORSE IS BETTER
GILLUM, SH
AS WOMEN OF FAITH: TALKS SELECTED FROM THE BRIGHAM YOUNG UNIV WOMENS CONFERENCES, 1989, : 196 - 200

← 1 2 3 4 5 →