Adjuvant Therapy for Urothelial and Renal Cell Carcinoma

被引：6
|
作者：
Patel, Hiten D. [1 ,2 ]
Kates, Max [1 ,2 ]
Allaf, Mohamad E. [1 ,2 ]
机构：
[1] Johns Hopkins Univ, Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Med, Dept Urol, 600 N Wolfe St, Baltimore, MD 21287 USA
来源：
EUROPEAN UROLOGY FOCUS | 2020年 / 6卷 / 01期
关键词：
CHEMOTHERAPY; CYSTECTOMY;
D O I：
10.1016/j.euf.2019.04.007
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Adjuvant therapy for urothelial and renal cell carcinoma has progressed steadily over the past 30 yr. Level 1 evidence supports a role for both neoadjuvant and adjuvant cisplatin-based chemotherapy for muscle-invasive urothelial carcinoma of the bladder. Recent evidence has also confirmed a benefit from adjuvant therapy in high-grade upper tract urothelial carcinoma. Adjuvant targeted therapy remains controversial and outside the standard of care for renal cell carcinoma, with no proven overall survival benefit. Immune checkpoint blockade is poised to shift the landscape for both urothelial and renal cell carcinoma with the potential for greater efficacy. (C) 2019 European Association of Urology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：3 / 6
页数：4
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