Synthesis and antiviral evaluation of α-D-2′,3′-didehydro-2′,3′-dideoxy-3′-C-hydroxymethyl nucleosides

被引：3
|
作者：
Yamada, Kohei [1 ]
Hayakawa, Hiroyuki [1 ]
Sakata, Shinji [1 ]
Ashida, Noriyuki [1 ]
Yoshimura, Yuichi [2 ]
机构：
[1] Yamasa Corp, Div Biochem, Chiba 2880056, Japan
[2] Tohoku Pharmaceut Univ, Aoba Ku, Sendai, Miyagi 9818558, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 20期
关键词：
Nucleosides; Antiviral; S(N)2 ' Reaction; PYRIMIDINE NUCLEOSIDES; ALTERNATIVE SYNTHESIS; BIOLOGICAL-ACTIVITIES; ALLYLIC SELENIDES; SUGAR MOIETY; NUCLEOTIDES; OXETANOCIN; HIV; AGENTS; ISONUCLEOSIDES;
D O I：
10.1016/j.bmcl.2010.08.071
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have identified a selective S(N)2' reaction triggered by iodide ion that leads to the ring-opening of 2,2'-anhydro-alpha-nucleosides. By applying the method, we have synthesized alpha-D-2',3'-didehydro-2',3'-dideoxy- 3'-C-hydroxymethyl nucleosides, designed as potential antiviral agents. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6013 / 6016
页数：4
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