Therapy-induced senescence - an induced synthetic lethality in liver cancer?

被引：10
|
作者：
Wolter, Katharina [1 ,2 ]
Zender, Lars [1 ,2 ,3 ]
机构：
[1] Univ Hosp Tubingen, Dept Med Oncol & Pneumol Internal Med 8, Tubingen, Germany
[2] Eberhard Karls Univ Tubingen, Cluster Excellence Image Guided & Functionally In, Tubingen, Germany
[3] German Canc Res Ctr, German Consortium Translat Canc Res DKTK, Partner Site Tubingen, Heidelberg, Germany
来源：
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2020年 / 17卷 / 03期
基金：
欧洲研究理事会;
关键词：
SURVEILLANCE; DISEASES; CELLS;
D O I：
10.1038/s41575-020-0262-3
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Cancer therapies, in addition to inducing cell death, can trigger cellular senescence of tumour cells, and factors secreted from senescent cells might negatively affect the tumour microenvironment. A new study by Wang et al. shows that eradication of therapy-induced senescent cells (senolysis) can improve the outcome of liver cancer therapy.
引用
收藏
页码：135 / 136
页数：2
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