Therapy-induced senescence - an induced synthetic lethality in liver cancer?

被引：10

作者：

Wolter, Katharina ^{[1
,2
]}

Zender, Lars ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Tubingen, Dept Med Oncol & Pneumol Internal Med 8, Tubingen, Germany

[2] Eberhard Karls Univ Tubingen, Cluster Excellence Image Guided & Functionally In, Tubingen, Germany

[3] German Canc Res Ctr, German Consortium Translat Canc Res DKTK, Partner Site Tubingen, Heidelberg, Germany

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2020年 / 17卷 / 03期

基金：

欧洲研究理事会;

关键词：

SURVEILLANCE; DISEASES; CELLS;

D O I：

10.1038/s41575-020-0262-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cancer therapies, in addition to inducing cell death, can trigger cellular senescence of tumour cells, and factors secreted from senescent cells might negatively affect the tumour microenvironment. A new study by Wang et al. shows that eradication of therapy-induced senescent cells (senolysis) can improve the outcome of liver cancer therapy.

引用

页码：135 / 136

页数：2

共 50 条

[1] Therapy-induced senescence — an induced synthetic lethality in liver cancer?
Katharina Wolter
Lars Zender
[J]. Nature Reviews Gastroenterology & Hepatology, 2020, 17 : 135 - 136
[2] Therapy-Induced Senescence in Cancer
Ewald, Jonathan A.
Desotelle, Joshua A.
Wilding, George
Jarrard, David F.
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2010, 102 (20) : 1536 - 1546
[3] Biological functions of therapy-induced senescence in cancer
Fitsiou, Eleni
Soto-Gamez, Abel
Demaria, Marco
[J]. SEMINARS IN CANCER BIOLOGY, 2022, 81 : 5 - 13
[4] Leveraging therapy-induced senescence for prostate cancer immunotherapy
Zhou, Lin
Murphy, Katherine C.
Snyder, Jarin
DeMarco, Kelly D.
Ma, Boyang
Ruscetti, Marcus
[J]. CANCER RESEARCH, 2023, 83 (11)
[5] Therapy-induced senescence: Friend or foe?
Stewart, Sheila
[J]. CANCER RESEARCH, 2023, 83 (05)
[6] Cancer Response to Therapy-Induced Senescence: A Matter of Dose and Timing
Mongiardi, Maria Patrizia
Pellegrini, Manuela
Pallini, Roberto
Levi, Andrea
Falchetti, Maria Laura
[J]. CANCERS, 2021, 13 (03) : 1 - 16
[7] Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells
Mikula-Pietrasik, Justyna
Niklas, Arkadiusz
Uruski, Pawel
Tykarski, Andrzej
Ksiazek, Krzysztof
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2020, 77 (02) : 213 - 229
[8] Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence
Abdelgawad, Ibrahim Y.
Sadak, Karim T.
Lone, Diana W.
Dabour, Mohamed S.
Niedernhofer, Laura J.
Zordoky, Beshay N.
[J]. PHARMACOLOGY & THERAPEUTICS, 2021, 221
[9] Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells
Justyna Mikuła-Pietrasik
Arkadiusz Niklas
Paweł Uruski
Andrzej Tykarski
Krzysztof Książek
[J]. Cellular and Molecular Life Sciences, 2020, 77 : 213 - 229
[10] RNAi-induced synthetic lethality in cancer therapy
Dai, Bingbing
Fang, Bingliang
Roth, Jack A.
[J]. CANCER BIOLOGY & THERAPY, 2009, 8 (23) : 2314 - 2316

← 1 2 3 4 5 →