MicroRNA-23a suppresses the apoptosis of inflammatory macrophages and foam cells in atherogenesis by targeting HSP90

被引：11
|
作者：
Qiao, Yu [1 ,2 ,5 ]
Wang, Chuxuan [1 ,2 ,3 ,5 ]
Kou, Jiayuan [1 ,2 ,5 ]
Wang, Lujing [1 ,2 ,5 ]
Han, Dong [1 ,2 ,5 ]
Huo, Da [1 ,2 ,5 ]
Li, Fuyan [1 ,2 ,5 ]
Zhou, Xiaoxi [1 ,2 ,5 ]
Meng, Dehao [1 ,2 ,5 ]
Xu, Jiaran [1 ,2 ,5 ]
Murtaza, Ghulam [1 ,2 ,5 ]
Artyom, Bobkov [1 ,2 ,5 ]
Ma, Ning [1 ,2 ,5 ]
Luo, Shanshun [4 ]
机构：
[1] Harbin Med Univ, Dept Biochem & Mol Biol, Harbin, Peoples R China
[2] Harbin Med Univ, Key Lab Cardiovasc Med Res, Minist Educ, Harbin, Peoples R China
[3] Harbin Med Univ, Translat Med Ctr Northern China, Harbin, Peoples R China
[4] Harbin Med Univ, Hosp 1, Dept Gerontol, Harbin, Peoples R China
[5] Med Sci Inst Hei Longjiang Prov, Harbin, Peoples R China
来源：
GENE | 2020年 / 729卷
基金：
中国国家自然科学基金;
关键词：
miR-23a; HSP90; Inflammatory response; Apoptosis; HEAT-SHOCK PROTEINS; MIR-23A; ATHEROSCLEROSIS; MECHANISMS; EXPRESSION; ALPHA;
D O I：
10.1016/j.gene.2019.144319
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In previous study, we have found that microRNA-23a is down regulated in atherosclerotic tissues. Here we demonstrate that miR-23a directly binds to 3'UTR of HSP90 mRNA to suppress the expression of HSP90. To investigate the potential roles of miR-23a in macrophage, THP-1 macrophages were transfected with miR-23a mimics or inhibitors. Our results showed inflammatory factors IL-6 and MCP-1 concentrations in cell culture medium of macrophage and foam cell transfected with miR-23a mimics were decreased. Furthermore, we find that apoptosis of macrophage and foam cells transfected with miR-23a mimics were inhibited. Over expression of miR-23a in foam cells could reduced lipid intake and accumulation in foam cells. Meanwhile, we found that in inflammatory macrophages and foam cells transfected with miR-23a mimcs, HSP90 and NF-kappa B proteins are significantly decreased. Our results have suggested a promising and potential therapeutic target for atherosclerosis.
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页数：7
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