The effects of static surface deformations on a spatially developing supersonic boundary layer flow at Mach number M = 4 and Reynolds number Re-delta in 49300, based on inflow boundary layer thickness AO, are analyzed by performing large eddy simulations. Two low-order structural modes of a rectangular clamped surface panel of dimensions 33(delta in) x 48(delta in) are prescribed with modal amplitudes of (delta in). The effects of these surface deformations are examined on the boundary layer, including changes in the mean properties, thermal and compressibility effects and turbulence structure. The results are analyzed in the context of deviations from concepts typically derived and employed for equilibrium turbulence. The surface deflections, to some degree, modify the correlations that govern both Morkovin's hypothesis and strong Reynolds analogy away from the wall, whereas in the near-wall region both the hypotheses breakdown. Modifications to the turbulence structure due to the surface deformations are elucidated by means of the wall pressure two-point correlations and anisotropy invariant maps. In addition to the amplification of turbulence, such surface deformations lead to local flow separation, instigating low-frequency unsteadiness. One consequence of significance to practical design is the presence of low frequency unsteadiness similar to that encountered in impinging or ramp shock boundary layer interactions. (C) 2021 Elsevier Masson SAS. All rights reserved.