Demetallation of organometallic and metal-mediated reactions

The use of stoichiometric organometallic reagents and stoichiometric metals formed the basis of vast majority of classical reactions for constructing carbon-carbon bonds. The indispensable requirement of stoichiometric metals for such reactions constitutes significant challenges in terms of resource sustainability, operational safety, and chemical-waste management. The recent developments in C-H functionalizations, hydrogenative alkene/alkyne addition to electrophiles, the hydrazone umpolung chemistry, and other emerging fields such as the electrosynthesis and photoredox chemistry provide potential solutions to overcome these inherent challenges.