Plasma concentrations of three methylated arginines, endogenous nitric oxide synthase inhibitors, in schizophrenic patients undergoing antipsychotic drug treatment

被引:8
|
作者
Nonaka-Hashida, Satoko [1 ,2 ]
Sekine, Masae [1 ]
Ozeki, Yuji [3 ]
Fujii, Kumiko [3 ]
Akiyama, Kazufumi [4 ]
Shimoda, Kazutaka [3 ]
Tsunoda, Makoto [5 ]
Katane, Masumi [1 ]
Saitoh, Yasuaki [1 ]
Miyamoto, Tetsuya [1 ]
Homma, Hiroshi [1 ]
机构
[1] Kitasato Univ, Grad Sch Pharmaceut Sci, Tokyo, Japan
[2] Tokyo Labs, Pfizer Worldwide Res & Dev, Tokyo, Japan
[3] Dokkyo Med Univ, Sch Med, Dept Psychiat, Mibu, Tochigi, Japan
[4] Dokkyo Med Univ, Sch Med, Dept Biol Psychiat & Neurosci, Mibu, Tochigi, Japan
[5] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo, Japan
关键词
Schizophrenia; L-NMMA; ADMA; SDMA; L-arginine; NOS inhibitor; ASYMMETRIC DIMETHYLARGININE ADMA; TANDEM MASS-SPECTROMETRY; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; CEREBROSPINAL-FLUID; ENDOTHELIAL DYSFUNCTION; REFLECT ABNORMALITIES; SERUM METHYLARGININES; DIABETES-MELLITUS; BIOLOGICAL-FLUIDS;
D O I
10.1016/j.psychres.2016.02.029
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Plasma concentration of three methylated arginines, endogenous nitric oxide synthase inhibitors, is not studied in schizophrenic patients. The purpose of this study was to determine plasma concentrations of N-G-monomethyl-L-arginine (L-NMMA), N-G,N-G-dimethyl-L-arginine (ADMA), N-G,N-G'-dimethyl-L-arginine (SDMA), and L-arginine in 56 male and 45 female schizophrenic patients undergoing antipsychotic drug treatment versus those of 39 male and 24 female healthy controls. Plasma concentrations of methylated arginines and L-arginine were measured using newly developed high performance liquid chromatography with fluorescence detection which we previously reported. Methylated arginine levels were slightly but significantly higher in schizophrenic patients. L-Arginine levels and the L-arginine/(ADMA+L-NMMA) ratio were higher in schizophrenic patients than in healthy controls. It is considered that pharmacological treatment of schizophrenic patients may lower methylated arginine levels that are increased by the disease, and increase L-arginine levels, eliciting an improvement in nitric oxide (NO) bioavailability. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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页码:203 / 210
页数:8
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