DNA-binding and photocleavage studies of [Ru(phen)2(NMIP)]2+

被引：39
|
作者：
Tan, LF
Chao, H
Liu, YJ
Li, H
Sun, B
Ji, LN
机构：
[1] Sun Yat Sen Univ, Dept Chem, Guangzhou 510275, Peoples R China
[2] Sun Yat Sen Univ, Minist Educ, Key Lab Gene Engn, Guangzhou 510275, Peoples R China
[3] Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China
[4] So China Normal Univ, Dept Chem, Guangzhou 510000, Peoples R China
来源：
INORGANICA CHIMICA ACTA | 2005年 / 358卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ruthenium(II) complex; polypyridyl ligand; DNA-binding; photocleavage;
D O I：
10.1016/j.ica.2004.10.030
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A novel ligand 2'-(2"-nitro-3",4"-methylenedioxyphenyl)imidazo[4',5'-f][1,10]-phenanthroline (NMIP) and its complex [Ru(phen)(2)(NMIP)](2+) have been synthesized and characterized by mass spectroscopy, H-1 NMR and cyclic voltammetry. Binding of the complex with calf thymus DNA (CT DNA) has been investigated by spectroscopic methods, viscosity and electrophoresis measurements. The experimental results indicate that [Ru(phen)(2)(NMIP)](2+) binds to DNA via partial intercalative mode and the individual enantiomers of it bind to DNA in different rates. [Ru(phen)(2)(NMIP)](2+) has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled Form I to the open circular Form 11 upon irradiation. (c) 2004 Published by Elsevier B.V.
引用
收藏
页码：2191 / 2198
页数：8
相关论文
共 50 条
  • [31] Synthesis, DNA-binding and photocleavage studies of the ruthenium(II) complexes [Ru(phen)2(ppd)]2+ and [Ru(phen)(ppd)2]2+ (ppd = pteridino[6,7-f] [1,10]phenanthroline-11,13(10H,12H)-dione, phen=1,10-phenanthroline)
    Gao, Feng
    Chao, Hui
    Wei, Yuan-Fang
    Yuan, Yi-Xian
    Peng, Bin
    Chen, Xin
    Zheng, Kang-Cheng
    Ji, Liang-Nian
    HELVETICA CHIMICA ACTA, 2008, 91 (03) : 395 - 410
  • [32] Turning on DNA photocleavage by Ru(bpy)2(pteridine)2+ complexes
    Williams, Benjamin
    Gaudette, Alexandra
    Skiba, Meredith
    Burgmayer, Sharon
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [33] Synthesis, characterization, DNA-binding and cleavage studies of [Ru(bpy)2(actatp)]2+ and [Ru(phen)2(actatp)]2+ (actatp=acenaphthereno[1,2-b]-1,4,8,9-tetraazariphenylence)
    Deng, H
    Xu, H
    Yang, Y
    Li, H
    Zou, H
    Qu, LH
    Ji, LN
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 97 (02) : 207 - 214
  • [34] DFT/TDDFT STUDY ON DNA-BINDING AND SPECTRAL PROPERTIES OF "LIGHT SWITCH" COMPLEX [Ru(phen)2 (taptp)]2+ IN AQUEOUS SOLUTION
    Li, Jun
    Xu, Lian-Cai
    Liao, Si-Yan
    Zheng, Kang-Cheng
    Ji, Liang-Nian
    JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY, 2008, 7 (06): : 1147 - 1158
  • [35] BINDING OF DELTA-[RU(PHEN)(3)](2+) AND LAMBDA-[RU(PHEN)(3)](2+) TO [D(CGCGATCGCG)](2) STUDIED BY NMR
    ERIKSSON, M
    LEIJON, M
    HIORT, C
    NORDEN, B
    GRASLUND, A
    BIOCHEMISTRY, 1994, 33 (17) : 5031 - 5040
  • [36] BINDING OF RU(BPY)3(2+) AND RU(PHEN)3(2+) TO POLYNUCLEOTIDES AND DNA - EFFECT OF ADDED SALTS ON THE ABSORPTION AND LUMINESCENCE PROPERTIES
    GORNER, H
    TOSSI, AB
    STRADOWSKI, C
    SCHULTEFROHLINDE, D
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1988, 2 (01) : 67 - 89
  • [37] Synthesis, Characterization, and DNA-Binding of Chiral Complexes Δ- and Λ-[Ru(bpy)2(pyip)]2+
    Shi, Shuo
    Yao, Tian-Ming
    Geng, Xiao-Ting
    Jiang, Ling-Feng
    Liu, Jie
    Yang, Qing-Yuan
    Ji, Liang-Nian
    CHIRALITY, 2009, 21 (02) : 276 - 283
  • [38] Efficient DNA photocleavage by [Ru(bpy)2(dppn)]2+ with visible light
    Sun, Yujie
    Joyce, Lauren E.
    Dickson, Nicole M.
    Turro, Claudia
    CHEMICAL COMMUNICATIONS, 2010, 46 (14) : 2426 - 2428
  • [39] DNA-binding, cytotoxicity, cellular uptake, apoptosis and photocleavage studies of Ru(II) complexes
    Deepika, N.
    Devi, C. Shobha
    Kumar, Y. Praveen
    Reddy, K. Laxma
    Reddy, P. Venkat
    Kumar, D. Anil
    Singh, Surya S.
    Satyanarayana, S.
    JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2016, 160 : 142 - 153
  • [40] Structure, spectroscopy, and DNA binding of a novel molecular light switch, [Ru(phen)2(bptt)]2+
    Robinson, Brigitte R.
    Kraft, Brian J.
    Hughes, Chris G.
    Zaleski, Jeffrey M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 930 - 930
12345