Gut insulin from Foxo1 loss

被引：0

作者：

Kim, Seung K. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Dev Biol, Div Oncol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Med, Div Oncol, Sch Med, Stanford, CA 94305 USA

[3] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 04期

关键词：

BETA-CELLS; IN-VIVO; NEUROGENIN-3; EXPRESSION; GENE;

D O I：

10.1038/ng.2226

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Neuroendocrine cells, including those in the gut, have a vast array of functions. A new study shows that conditional inactivation of the gene encoding Foxo1 in mouse intestinal endocrine cells converts them into cells synthesizing and secreting insulin. Ectopic gut insulin production was sufficient to ameliorate glucose control in mice with conditional pancreatic beta-cell loss and diabetes mellitus.

引用

页码：363 / 364

页数：2

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