Novel chitosan derivatives of 2-imidazolecarboxaldehyde and 2-thiophenecarboxaldehyde and their antibacterial activity

被引：26
|
作者：
Yadav, Manoj Kumar [1 ]
Pokhrel, Shanta [2 ]
Yadav, Paras Nath [1 ]
机构：
[1] Tribhuvan Univ, Cent Dept Chem, Kathmandu, Nepal
[2] Tribhuvan Univ, Dept Chem, Trichandra Multiple Campus, Kathmandu, Nepal
来源：
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2020年 / 57卷 / 10期
关键词：
Antibacterial activity; chitosan-imidazole; chitosan-thiophene; C-13-NMR spectroscopy; FTIR; TGA; ANTIMICROBIAL ACTIVITY; SCHIFF-BASE; DEACETYLATION; CHITIN; ACETYLATION; WATER; ACID;
D O I：
10.1080/10601325.2020.1763809
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Chitosan was synthesized from chitin; extracted from prawn shells' powder via deacetylation and physicochemical properties were studied. Novel chitosan derivatives of 2-imidazolecarboxaldehyde and 2-thiophenecarboxaldehyde were synthesized by refluxing equimolar quantities of respective aldehyde with chitosan. These functionalized chitosan derivatives were characterized by Fourier transform infrared (FTIR), C-13-nuclear magnetic resonance (C-13-NMR) spectroscopy, elemental analysis, X-ray diffraction (XRD), thermogravimetric analysis (TGA) and differential thermal analysis (DTA) and their antibacterial activity was explored. Chitosan derivative of 2-thiophenecarboxaldehyde was found active against Escherichia coli.
引用
收藏
页码：703 / 710
页数：8
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