Synthesis of thiazolyl benzimidazoles and thiazolyl coumarins linked to isoxazole as possible biodynamic agents

A new series of linked heterocyclics, 5-(1H-benzo[d]imidazo-l2-yl-methyl)-3-(3-methyl-5-[(E)-2-phenyl-1-ethenyl]-4-isoxazolyl)-2-aryl-1,3-thiazolan-4-ones 4 and 3-{3-methyl-5-[(E)-2-phenyl-1-ethenyl]-4-isoxazolyl}-5-(2-oxo-2H-3-chromenyl)-2-aryl-1,3-thiazolan-4-ones 5 have been synthesized by the cyclocondensation of 4-benzalamino-3-methyl-5-styrylisoxazole 2 with mercapto succinic acid followed by cyclization with 1,2-phenylenediamines or salicylaldehydes. Structures of all the newly synthesized compounds 3-5 have been confirmed by spectral and micro analytical data.