Evolution of autoantibody responses in individuals at risk of rheumatoid arthritis

被引：12
|
作者：
Falkenburg, Willem J. J. [1 ,2 ]
van Schaardenburg, Dirkjan [1 ,3 ]
机构：
[1] Amsterdam Rheumatol & Immunol Ctr, Reade, Doctor Jan Van Breemenstr 2, NL-1056 AB Amsterdam, Netherlands
[2] Sanquin Res, Dept Immunopathol, POB 9892, NL-1006 AN Amsterdam, Netherlands
[3] Acad Med Ctr, Amsterdam Rheumatol & Immunol Ctr, POB 22660, NL-1100 DD Amsterdam, Netherlands
来源：
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2017年 / 31卷 / 01期
关键词：
Arthralgia; Pre-clinical rheumatoid arthritis; Rheumatoid factors; Anti-citrullinated protein antibodies; Epitope spreading; Glycosylation; Autoantibody interactions; CITRULLINATED PROTEIN ANTIBODIES; COLLAGEN-INDUCED ARTHRITIS; CD5+ B-CELLS; CONSTANT-REGION; INTRAVENOUS IMMUNOGLOBULINS; SEROPOSITIVE ARTHRALGIA; CARBAMYLATED PROTEINS; MEDIATED INFLAMMATION; AUTOIMMUNE-DISEASES; PEPTIDE ANTIBODIES;
D O I：
10.1016/j.berh.2017.07.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoantibodies such as rheumatoid factors (RFs), anti-citrullinated protein antibodies (ACPAs), and other anti-modified protein anti-bodies are important risk factors for the development of rheumatoid arthritis (RA) and probably play an important role in its pathogenesis. In the phase before clinical arthritis becomes apparent, different autoantibody responses can evolve because of increases in their level, isotype switching, affinity maturation, epitope spreading, and a changing glycosylation profile. This evolution may be crucial for the pathogenic properties of the autoantibody responses, and interfering with this process in individuals at risk may become a route to prevent RA. Recent data suggest that interactions between RFs and ACPAs further amplify their inflammatory potential. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：42 / 52
页数：11
相关论文
共 50 条
  • [41] Expansion of antiphospholipid autoantibody screen in rheumatoid arthritis
    Sherer, Y.
    Amital, H.
    Shepshelovich, D.
    Barzilai, O.
    Blank, M.
    Larida, B.
    Shoenfeld, Y.
    ALLERGY, 2008, 63 : 271 - 272
  • [42] Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis
    Milchram, Lisa
    Fischer, Anita
    Huber, Jasmin
    Soldo, Regina
    Sieghart, Daniela
    Vierlinger, Klemens
    Blueml, Stephan
    Steiner, Guenter
    Weinhaeusel, Andreas
    MOLECULES, 2022, 27 (04):
  • [43] Autoantibody diagnostic and prognostic markers of rheumatoid arthritis
    Sibilia, J
    PRESSE MEDICALE, 2000, 29 (31): : 1723 - 1730
  • [44] AUTOANTIBODY STUDIES IN JUVENILE RHEUMATOID-ARTHRITIS
    LAWRENCE, JM
    MOORE, TL
    OSBORN, TG
    NESHER, G
    MADSON, KL
    KINSELLA, MB
    SEMINARS IN ARTHRITIS AND RHEUMATISM, 1993, 22 (04) : 265 - 274
  • [45] Synovial and serum B cell signature of autoantibody-negative rheumatoid arthritis vs autoantibody-positive rheumatoid arthritis and psoriatic arthritis
    De Stefano, Ludovico
    Bugatti, Serena
    Mazzucchelli, Iolanda
    Rossi, Silvia
    Xoxi, Blerina
    Cassione, Emanuele Bozzalla
    Luvaro, Terenzj
    Montecucco, Carlomaurizio
    Manzo, Antonio
    RHEUMATOLOGY, 2023, : 1322 - 1331
  • [46] THE DIAGNOSTIC VALUE OF AUTOANTIBODY ISOTYPES IN RHEUMATOID ARTHRITIS
    Sieghart, D.
    Platzer, A.
    Studenic, P.
    Alasti, F.
    Grundhuber, M.
    Swiniarski, S.
    Blueml, S.
    Haslacher, H.
    Smolen, U.
    Steiner, G.
    ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 : 807 - 808
  • [47] EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis
    Gerlag, Danielle M.
    Raza, Karim
    van Baarsen, Lisa G. M.
    Brouwer, Elisabeth
    Buckley, Christopher D.
    Burmester, Gerd R.
    Gabay, Cem
    Catrina, Anca I.
    Cope, Andrew P.
    Cornelis, Francois
    Dahlqvist, Solbritt Rantapaa
    Emery, Paul
    Eyre, Stephen
    Finckh, Axel
    Gay, Steffen
    Hazes, Johanna M.
    van der Helm-van Mil, Annette
    Huizinga, Tom W. J.
    Klareskog, Lars
    Kvien, Tore K.
    Lewis, Cathryn
    Machold, Klaus P.
    Ronnelid, Johan
    van Schaardenburg, Dirkjan
    Schett, Georg
    Smolen, Josef S.
    Thomas, Sue
    Worthington, Jane
    Tak, Paul P.
    ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (05) : 638 - 641
  • [48] Associations between an expanded autoantibody profile and treatment responses to biologic therapies in patients with rheumatoid arthritis
    Petro, Alison D.
    Dougherty, Joseph
    England, Bryant R.
    Sayles, Harlan
    Duryee, Michael J.
    Hunter, Carlos D.
    Kremer, Joel M.
    Pappas, Dimitrios A.
    Robinson, William H.
    Curtis, Jeffrey R.
    Thiele, Geoffrey M.
    Mikuls, Ted R.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 91
  • [49] ULTRASOUND DETECTED TENOSYNOVITIS PREDICTS ARTHRITIS ONSET IN INDIVIDUALS AT RISK OF DEVELOPING RHEUMATOID ARTHRITIS
    Kisten, Y.
    Rezaei, H.
    af Klint, E.
    Fei, G.
    Antovic, A.
    Hensvold, A. H.
    Catrina, A. I.
    ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 : 287 - 288
  • [50] Tenosynovitis Detected By Ultrasound Predicts Arthritis Onset in Individuals at Risk of Developing Rheumatoid Arthritis
    Kisten, Yogan
    Rezaei, Hamed
    af Klint, Erik
    Fei, Guozhong
    Antovic, Aleksandra
    Hensvold, Aase
    Catrina, Anca I.
    ARTHRITIS & RHEUMATOLOGY, 2018, 70
12345