Preparation of core/shell NaYF4:Yb,Tm@dendrons nanoparticles with enhanced upconversion luminescence for in vivo imaging

被引:14
|
作者
Francolon, Nadege [1 ]
Boyer, Damien [1 ]
Leccia, Felicia [2 ]
Jouberton, Elodie [3 ,4 ]
Walter, Aurelie [5 ]
Bordeianu, Catalina [5 ]
Parat, Audrey [5 ]
Felder-Flesch, Delphine [5 ]
Begin-Colin, Sylvie [5 ]
Miot-Noirault, Elisabeth [3 ]
Chezal, Jean-Michel [3 ]
Mahiou, Rachid [1 ]
机构
[1] Univ Clermont Auvergne, Inst Chim Clermont Ferrand, UMR CNRS UBP Sigma Clermont 6296, Aubiere, France
[2] Univ Clermont Auvergne, Genet Reprod & Dev, CNRS, UMR 6247,INSERM,U931, Clermont Ferrand, France
[3] Univ Clermont Auvergne, Imagerie Mol & Therapie Vectorisee, UMR 990, INSERM,UdA, Clermont Ferrand, France
[4] Ctr Lutte Canc Jean Perrin, Clermont Ferrand, France
[5] Univ Strasbourg, CNRS, Inst Phys & Chim Mat Strasbourg, UMR 7504, Strasbourg, France
关键词
Nanoparticle; Upconversion; Dendrons; Fluorescence imaging; YB3+;
D O I
10.1016/j.nano.2016.05.020
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Upconverting nanoparticles ( UCNPs) were successfully dendronized for fluorescence medical imaging applications. The structural and morphological characterizations of resulting core/shell NaYF4:Yb,Tm@dendrons nanoparticles were performed by means of X-ray diffraction, infrared spectroscopy and transmission electron microscopy. In vitro cytotoxicity assays have evidenced their low toxicity. In vivo fluorescence imaging study was performed in mice upon IR excitation, showing promising imaging capacities at low concentrations ( 0.5 mg/mL) and low power ( 50 mW/cm(2)). (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:2107 / 2113
页数:7
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