Neural Control of Energy Balance: Translating Circuits to Therapies

被引：186

作者：

Gautron, Laurent ^{[1
]}

Elmquist, Joel K. ^{[1
,2
]}

Williams, Kevin W. ^{[1
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA

来源：

CELL | 2015年 / 161卷 / 01期

关键词：

Y GASTRIC BYPASS; DIRECT-CURRENT STIMULATION; GLUCAGON-LIKE PEPTIDE-1; DEEP BRAIN-STIMULATION; CONTROLLED-RELEASE PHENTERMINE/TOPIRAMATE; REVERSES INSULIN-RESISTANCE; LATERAL HYPOTHALAMIC AREA; TYPE-2; DIABETES-MELLITUS; MELANOCORTIN; RECEPTORS; NEURONS REGULATE ENERGY;

D O I：

10.1016/j.cell.2015.02.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent insights into the neural circuits controlling energy balance and glucose homeostasis have rekindled the hope for development of novel treatments for obesity and diabetes. However, many therapies contribute relatively modest beneficial gains with accompanying side effects, and the mechanisms of action for other interventions remain undefined. This Review summarizes current knowledge linking the neural circuits regulating energy and glucose balance with current and potential pharmacotherapeutic and surgical interventions for the treatment of obesity and diabetes.

引用

页码：133 / 145

页数：13

共 50 条

[21] Nutrient Control of Energy Homeostasis via Gut-Brain Neural Circuits
Mithieux, Gilles
NEUROENDOCRINOLOGY, 2014, 100 (2-3) : 89 - 94
[22] Energy Efficiency in Adaptive Neural Circuits
Cauwenberghs, Gert
2017 FIFTH BERKELEY SYMPOSIUM ON ENERGY EFFICIENT ELECTRONIC SYSTEMS & STEEP TRANSISTORS WORKSHOP (E3S), 2017,
[23] Genetic control of active neural circuits
Reijmers, Leon
Mayford, Mark
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2009, 2
[24] The Role of PVH Circuits in Leptin Action and Energy Balance
Sutton, Amy K.
Myers, Martin G., Jr.
Olson, David P.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 78, 2016, 78 : 207 - 221
[25] Synaptic plasticity in neuronal circuits regulating energy balance
Zeltser, Lori M.
Seeley, Randy J.
Tschoep, Matthias H.
NATURE NEUROSCIENCE, 2012, 15 (10) : 1336 - 1342
[26] Food memory circuits regulate eating and energy balance
Pardo-Garcia, Thibaut R.
Gu, Kathleen
Woerner, Riley K. R.
Dus, Monica
CURRENT BIOLOGY, 2023, 33 (02) : 215 - +
[27] Synaptic plasticity in neuronal circuits regulating energy balance
Lori M Zeltser
Randy J Seeley
Matthias H Tschöp
Nature Neuroscience, 2012, 15 : 1336 - 1342
[28] Neural plasticity and the regulation of energy balance
Kokoeva, Maia
Robins, Sarah
FASEB JOURNAL, 2011, 25
[29] Benchmarking Delay and Energy of Neural Inference Circuits
Nikonov, Dmitri E.
Young, Ian A.
IEEE JOURNAL ON EXPLORATORY SOLID-STATE COMPUTATIONAL DEVICES AND CIRCUITS, 2019, 5 (02): : 75 - 84
[30] Endocannabinoids and the control of energy balance
Matias, Isabel
Di Marzo, Vincenzo
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2007, 18 (01): : 27 - 37

← 1 2 3 4 5 →