The pilocarpine model of epilepsy in mice

被引：163
|
作者：
Cavalheiro, EA
Santos, NF
Priel, MR
机构：
[1] Neurologia Experimental, UNIFESP-EPM, São Paula
[2] Neurologia Experimental, 04023-900 São Paulo
来源：
EPILEPSIA | 1996年 / 37卷 / 10期
关键词：
temporal lobe epilepsy; mossy fiber sprouting; recurrent spontaneous seizures; chronic epilepsy; mice;
D O I：
10.1111/j.1528-1157.1996.tb00541.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose: To characterize the acute and chronic behavioral, electrographic and histologic effects of sustained seizures induced by pilocarpine in mice. Methods: After status epilepticus, the surviving animals were continuously monitored for 24 h/day for less than or equal to 120 days. The brains were processed by using neo-Timm and Nissl stains. Results: The first spontaneous seizures occurred between 4 and 42 days after status epilepticus. The mean ''seizure-silent period'' lasted for 14.4 +/- 11.9 days. During the chronic phase, recurrent spontaneous seizures were observed 1-5 times per animal per week and were associated with sprouting in the supragranular layer of the dentate gyrus. Conclusions: Structural brain damage promoted by pilocarpine-induced status epilepticus may underlie or be associated with recurrent spontaneous seizures in mice.
引用
收藏
页码：1015 / 1019
页数：5
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