Facile synthesis of nitrophenyl 2-acetamido-2-deoxy-α-D-mannopyranosides from ManNAc-oxazoline

被引：4

作者：

Krenek, Karel ^{[1
]}

Simon, Petr ^{[1
]}

Weignerova, Lenka ^{[1
]}

Fliedrova, Barbora ^{[1
,2
]}

Kuzma, Marek ^{[1
]}

Kren, Vladimir ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Microbiol, CZ-14220 Prague, Czech Republic

[2] Charles Univ Prague, Dept Biochem, CZ-12840 Prague, Czech Republic

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 8卷

关键词：

alpha-ManNAc; glycosidase; glycosylation; nitrophenyl; oxazoline; NKR-P1; ACTIVATION;

D O I：

10.3762/bjoc.8.48

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthetic procedures for a large-scale preparation of o- and p-nitrophenyl 2-acetamido-2-deoxy-alpha-D-mannopyranoside are described. The synthetic pathway employs the glycosylation of phenol with ManNAc oxazoline, followed by nitration of the aromatic moiety yielding a separable mixture of the o- and p-nitrophenyl derivative in a 2:3 ratio.

引用

页码：428 / 432

页数：5

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