Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
被引:20
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作者:
Kim, Hye Sung
论文数: 0引用数: 0
h-index: 0
机构:
Jeju Natl Univ, Dept Pathol, Coll Med, Jeju, South KoreaJeju Natl Univ, Dept Pathol, Coll Med, Jeju, South Korea
Kim, Hye Sung
[1
]
Kim, Young Sil
论文数: 0引用数: 0
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机构:
Jeju Natl Univ, Dept Pathol, Coll Med, Jeju, South KoreaJeju Natl Univ, Dept Pathol, Coll Med, Jeju, South Korea
Kim, Young Sil
[1
]
Lee, Chul
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Pathol, Coll Med, Seoul, South KoreaJeju Natl Univ, Dept Pathol, Coll Med, Jeju, South Korea
Lee, Chul
[2
]
Shin, Myung Soo
论文数: 0引用数: 0
h-index: 0
机构:
Jeju Natl Univ, Dept Plast Surg, Coll Med, Jeju, South KoreaJeju Natl Univ, Dept Pathol, Coll Med, Jeju, South Korea
Shin, Myung Soo
[3
]
Kim, Jae Wang
论文数: 0引用数: 0
h-index: 0
机构:
Jeju Natl Univ, Dept Dermatol, Coll Med, Jeju, South KoreaJeju Natl Univ, Dept Pathol, Coll Med, Jeju, South Korea
Kim, Jae Wang
[4
]
Jang, Bo Gun
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机构:
Jeju Natl Univ, Dept Pathol, Coll Med, Jeju, South KoreaJeju Natl Univ, Dept Pathol, Coll Med, Jeju, South Korea
Jang, Bo Gun
[1
]
机构:
[1] Jeju Natl Univ, Dept Pathol, Coll Med, Jeju, South Korea
[2] Seoul Natl Univ, Dept Pathol, Coll Med, Seoul, South Korea
[3] Jeju Natl Univ, Dept Plast Surg, Coll Med, Jeju, South Korea
[4] Jeju Natl Univ, Dept Dermatol, Coll Med, Jeju, South Korea
来源:
PLOS ONE
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2019年
/
14卷
/
11期
关键词:
HAIR FOLLICLE;
STEM-CELLS;
HUMAN HOMOLOG;
GLI1;
ACTIVATION;
MUTATIONS;
PROTEIN;
LGR6;
D O I:
10.1371/journal.pone.0225511
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Basal cell carcinoma (BCC) is the most common human cancer, characterized by aberrant activation of the hedgehog (HH) signaling pathway resulting from mutations in the patched 1 (PTCH1) or smoothened (SMO) genes. In the present study, to uncover the expression profile of HH signaling-related molecules, we thoroughly examined the mRNA and protein expression levels of six molecules including GLI1, GLI2, PTCH1, PTCH2, SHH, and SMO in BCC and various other cutaneous tumors. Real-time PCR analysis demonstrated that BCC showed remarkably enhanced mRNA expression of all HH molecules, except SMO compared to other skin tumors. However, immunohistochemical analysis revealed that only GLI1 protein was specifically upregulated in BCC, while the other HH-related proteins did not show any significant differences between the tumors. Notably, other skin malignancies such as squamous cell carcinoma, sebaceous carcinoma, and malignant melanoma showed no GLI1 expression and there was no difference in GLI1 expression between the BCC subtypes. In addition, GLI1 and GLI2 expression were strongly associated with the hair follicle stem cell markers, LGR4 and LGR5, which are known target genes of the Wnt pathway. Our results suggest that GLI1 has the potential to be a diagnostically useful marker for differentiating BCC from other skin malignancies and an interaction between the HH and Wnt signaling pathways may be involved in the development of BCCs.
机构:
Univ Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Skin Dis Res Ctr, Birmingham, AL USA
Rutgers Robert Wood Johnson Med Sch, Piscataway, NJ USAUniv Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Bakshi, Anshika
Chaudhary, Sandeep C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Skin Dis Res Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Chaudhary, Sandeep C.
Rana, Mehtab
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Skin Dis Res Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Rana, Mehtab
Elmets, Craig A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Skin Dis Res Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Elmets, Craig A.
Athar, Mohammad
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
Univ Alabama Birmingham, Skin Dis Res Ctr, Birmingham, AL USAUniv Alabama Birmingham, Dept Dermatol, Volker Hall,Room 509,1530 3rd Ave South, Birmingham, AL 35294 USA
机构:
Scottsdale Healthcare, Virginia G Piper Canc Ctr Clin Trials, Scottsdale, AZ USA
Translat Genom Res Inst, Phoenix, AZ USAScottsdale Healthcare, Virginia G Piper Canc Ctr Clin Trials, Scottsdale, AZ USA
Weiss, Glen J.
Korn, Ronald L.
论文数: 0引用数: 0
h-index: 0
机构:
Scottsdale Med Imaging Ltd, Scottsdale, AZ USAScottsdale Healthcare, Virginia G Piper Canc Ctr Clin Trials, Scottsdale, AZ USA