ReCoGnizing methylated DNA

被引：22
|
作者：
Wade, PA [1 ]
Wolffe, AP
机构：
[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[2] Sangamo BioSci Inc, Richmond, CA 94804 USA
来源：
NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 07期
关键词：
D O I：
10.1038/89593
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The solution structure of a 5-methyl CpG dinucleotide in complex with the methyl-CpG binding domain from human MBD1 has provided new insights into how dinucleotide sequences are specifically recognized. Surprisingly, the methyl groups of the symmetrically methylated CpG sequence are each recognized in a distinct manner.
引用
收藏
页码：575 / 577
页数：3
相关论文
共 50 条
  • [41] Exploration of bladder cancer-associated methylated miRNAs by methylated DNA immunoprecipitation sequencing
    Gao, Xin
    Zheng, Wenwen
    Ye, Lili
    Wen, Xiaohong
    Wang, Shunlan
    Cao, Hui
    Liu, Xi
    Huang, Denggao
    Wang, Fei
    Zhang, Shufang
    ONCOTARGETS AND THERAPY, 2019, 12 : 6165 - 6174
  • [42] IS THE DNA OF VIRUS T7 METHYLATED
    AUER, B
    GUNTHERT, U
    WAGNER, EF
    SCHWEIGER, M
    JOURNAL OF GENERAL VIROLOGY, 1979, 44 (SEP): : 609 - 613
  • [43] METHYLATED BASES IN THE DNA OF THE CILIATE STYLONYCHIA MYTILUS
    AMMERMANN, D
    STEINBRUCK, G
    BAUR, R
    WOHLERT, H
    EUROPEAN JOURNAL OF CELL BIOLOGY, 1981, 24 (01) : 154 - 156
  • [44] Novel assay for detecting methylated DNA revealed
    不详
    BIOANALYSIS, 2009, 1 (06) : 1039 - 1039
  • [45] ABSENCE OF METHYLATED BASE IN DNA OF MICROCOCCUS RADIODURANS
    BERDAHL, B
    SCHEIN, AH
    FEDERATION PROCEEDINGS, 1972, 31 (02) : A838 - &
  • [46] RECOGNITION OF METHYLATED BASES IN DNA BY MAMMALIAN ENDONUCLEASES
    LAVIN, M
    KIKUCHI, T
    KIDSON, C
    PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 1972, 5 (NMAY): : 33 - &
  • [47] Hydration and recognition of methylated CpG steps in DNA
    Mayer-Jung, C
    Moras, D
    Timsit, Y
    EMBO JOURNAL, 1998, 17 (09): : 2709 - 2718
  • [48] REPAIR STUDIES ON METHYLATED DNA OF CHO CELLS
    KAINZBAUER, J
    SCHOKET, B
    STEHLIK, G
    ACTA BIOLOGICA HUNGARICA, 1990, 41 (1-3): : 109 - 113
  • [49] Detection of DNA methylated microRNAs in hepatocellular carcinoma
    Ezzat, Wafaa M.
    Amr, Khalda Said
    Elhosary, Yasser A.
    Hegazy, Abdelfattah E.
    Fahim, Hoda H.
    Eltaweel, Noha H.
    Kamel, Refaat R.
    GENE, 2019, 702 : 153 - 157
  • [50] Programming the transcriptional state of replicating methylated DNA
    Stünkel, W
    Ait-Si-Ali, S
    Jones, PL
    Wolffe, AP
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (23) : 20743 - 20749
12345