ReCoGnizing methylated DNA

被引：22

作者：

Wade, PA ^{[1
]}

Wolffe, AP

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[2] Sangamo BioSci Inc, Richmond, CA 94804 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2001年 / 8卷 / 07期

关键词：

D O I：

10.1038/89593

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The solution structure of a 5-methyl CpG dinucleotide in complex with the methyl-CpG binding domain from human MBD1 has provided new insights into how dinucleotide sequences are specifically recognized. Surprisingly, the methyl groups of the symmetrically methylated CpG sequence are each recognized in a distinct manner.

引用

页码：575 / 577

页数：3

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