In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

被引：0
|
作者：
Basaran, Ismet [1 ]
Sinan, Selma [2 ]
Cakir, Umit [1 ]
Bulut, Mustafa [3 ]
Arslan, Oktay [1 ]
Ozensoy, Ozen [1 ]
机构：
[1] Balikesir Univ, Sci & Art Fac, Dept Chem, TR-10100 Balikesir, Turkey
[2] Balikesir Univ, Sci & Art Fac, Dept Biol, TR-10100 Balikesir, Turkey
[3] Marmara Univ, Sci & Art Fac, Dept Chem, TR-81040 Istanbul, Turkey
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2008年 / 23卷 / 01期
关键词：
carbonic anhydrase; isozymes I and II; inhibitors; coumarin; phenols; cancer;
D O I：
10.1080/14756360701404100
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, namely 6,7-dihydroxy-3-phenyl-2H-chromen-2-one (DPC), were synthesized. These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.
引用
收藏
页码：32 / 36
页数：5
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