In vitro inhibition of cytosolic carbonic anhydrases I and II by some new dihydroxycoumarin compounds

被引：0

作者：

Basaran, Ismet ^{[1
]}

Sinan, Selma ^{[2
]}

Cakir, Umit ^{[1
]}

Bulut, Mustafa ^{[3
]}

Arslan, Oktay ^{[1
]}

Ozensoy, Ozen ^{[1
]}

机构：

[1] Balikesir Univ, Sci & Art Fac, Dept Chem, TR-10100 Balikesir, Turkey

[2] Balikesir Univ, Sci & Art Fac, Dept Biol, TR-10100 Balikesir, Turkey

[3] Marmara Univ, Sci & Art Fac, Dept Chem, TR-81040 Istanbul, Turkey

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2008年 / 23卷 / 01期

关键词：

carbonic anhydrase; isozymes I and II; inhibitors; coumarin; phenols; cancer;

D O I：

10.1080/14756360701404100

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of 6, 7-dihydroxy-3-(methylphenyl) chromenones, including three new derivatives, i.e. 6,7-dihydroxy-3-(2-methylphenyl)-2H-chromen-2-one (OPC); 6,7-dihydroxy-3-(3-methylphenyl)-2H-chromen-2-one (MPC); 6,7-dihydroxy-3-(4-methylphenyl)-2H-chromen-2-one (PPC) and one previously described, namely 6,7-dihydroxy-3-phenyl-2H-chromen-2-one (DPC), were synthesized. These compounds were investigated as inhibitors of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which had been purified from human erythrocytes on an affinity gel comprised of L-tyrosine-sulfonamide-Sepharose 4B.

引用

页码：32 / 36

页数：5

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