A Safer Synthesis of the Explosive Precursors 4-Aminofurazan-3-Carboxylic Acid and its Ethyl Ester Derivative

被引：3
|
作者：
Miller, Christopher W. [1 ]
Johnson, Eric C. [1 ]
Sausa, Rosario C. [2 ]
Orlicki, Joshua A. [3 ]
Sabatini, Jesse J. [1 ]
机构：
[1] CCDC US Army Res Lab, Energet Synth & Formulat Branch, Aberdeen Proving Ground, MD 21005 USA
[2] CCDC US Army Res Lab, Detonat Sci & Modeling Branch, Aberdeen Proving Ground, MD 21005 USA
[3] CCDC US Army Res Lab, Polymers Branch, Aberdeen Proving Ground, MD 21005 USA
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2020年 / 24卷 / 04期
关键词：
synthesis; heterocycles; energetic materials; process chemistry;
D O I：
10.1021/acs.oprd.0c00068
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A safe and efficient one-pot synthesis of 4-aminofurazan-3-carboxylic acid and its hydrogen chloride gas-free conversion to the ethyl ester derivative are described. Previous syntheses of these intermediates were plagued with mischaracterization issues, low yields, and/or dangerous exothermic profiles. The safe scale-up of these materials not only provides benefits to the energetic materials community but may also be of importance to the pharmaceutical and agrochemicals industries.
引用
收藏
页码：599 / 603
页数：5
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