Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity

被引：2

作者：

Fukakusa, Ayumi ^{[1
]}

Mizoguchi, Hiroyuki ^{[1
,2
]}

Koike, Hiroyuki ^{[1
]}

Nabeshima, Toshitaka ^{[3
]}

Takuma, Kazuhiro ^{[1
]}

Yamada, Kiyofumi ^{[1
,4
,5
]}

机构：

[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Lab Neuropsychopharmacol, Kanazawa, Ishikawa 9201192, Japan

[2] Nagoya Univ, Res Inst Environm Med, Futurist Environm Simulat Ctr, Nagoya, Aichi 4648601, Japan

[3] Meijo Univ, Grad Sch Pharmaceut Sci, Dept Chem Pharmacol, Nagoya, Aichi 4668503, Japan

[4] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol, Nagoya, Aichi 4668560, Japan

[5] Nagoya Univ, Grad Sch Med, Hosp Pharm, Nagoya, Aichi 4668560, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2008年 / 106卷 / 02期

关键词：

methamphetamine; neurotoxicity; tissue plasminogen activator;

D O I：

10.1254/jphs.SC0070328

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To investigate the role of tissue Plasminogen activator (tPA) in methamphetamine (METH)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) levels in the striatum after repetitive treatment of METH at 4 mg/kg among wild-type, tPA-deficient (tPA-/-), and protease activated receptor-l-deficient (PAR-1-/-) mice. METH treatment caused a marked decrease in TH and DAT levels in the striatum of those mice with a similar magnitude. No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo.

引用

页码：321 / 324

页数：4

共 50 条

[31] DOPAMINE-GLUTAMATE INTERACTIONS IN METHAMPHETAMINE-INDUCED NEUROTOXICITY
MARSHALL, JF
ODELL, SJ
WEIHMULLER, FB
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1993, 91 (2-3) : 241 - 254
[32] METHAMPHETAMINE-INDUCED NEUROTOXICITY - STRUCTURE-ACTIVITY-RELATIONSHIPS
KLEVEN, MS
SEIDEN, LS
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 654 : 292 - 301
[33] METHAMPHETAMINE-INDUCED NEUROTOXICITY - ROLES FOR GLUTAMATE AND DOPAMINE EFFLUX
STEPHANS, SE
YAMAMOTO, BK
SYNAPSE, 1994, 17 (03) : 203 - 209
[34] Methamphetamine-induced neurotoxicity: the road to Parkinson’s disease
Bessy Thrash
Kariharan Thiruchelvan
Manuj Ahuja
Vishnu Suppiramaniam
Muralikrishnan Dhanasekaran
Pharmacological Reports, 2009, 61 : 966 - 977
[35] MOTOR IMPAIRMENTS AFTER METHAMPHETAMINE-INDUCED NEUROTOXICITY IN THE RAT
WALSH, SL
WAGNER, GC
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1992, 263 (02): : 617 - 626
[36] Behavioral consequences of methamphetamine-induced neurotoxicity in mice: Relevance to the psychopathology of methamphetamine addiction
Itzhak, Y
Ali, SF
CELLULAR AND MOLECULAR MECHANISMS OF DRUGS OF ABUSE II: COCAINE, SUBSTITUTED AMPHETAMINES, GHB, AND OPIATES, 2002, 965 : 127 - 135
[37] Protective Effects of Isoliquiritigenin Against Methamphetamine-Induced Neurotoxicity in Mice
Lee, Min Jung
Yang, Chae Ha
Jeon, Jae-Pil
Hwang, Meeyul
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 111 (02) : 216 - 220
[38] Effects of Housing on Methamphetamine-Induced Neurotoxicity and Spatial Learning and Memory
Gutierrez, Arnold
Jablonski, Sarah A.
Amos-Kroohs, Robyn M.
Barnes, Anna C.
Williams, Michael T.
Vorhees, Charles V.
ACS CHEMICAL NEUROSCIENCE, 2017, 8 (07): : 1479 - 1489
[39] Baicalein reverses the methamphetamine-induced striatal dopaminergic neurotoxicity in mice
Liu, Yen-Yin
Yeh, Pen-Ho
Wang, Guei-Jane
Huang, Seng-Wong
Chi, Chin-Wen
Ho, Li-Kang
Pan, Wynn H. T.
JOURNAL OF FOOD AND DRUG ANALYSIS, 2006, 14 (04) : 317 - 322
[40] The Role of Non-coding RNAs in Methamphetamine-Induced Neurotoxicity
Xu, Luyao
Li, Lingyue
Chen, Qianling
Huang, Yuebing
Chen, Xuebing
Qiao, Dongfang
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2023, 43 (06) : 2415 - 2436

← 1 2 3 4 5 →