ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer

被引：7

作者：

Neyrinck-Leglantier, Deborah ^{[1
]}

Lesage, Julien ^{[1
,2
]}

Blacher, Silvia ^{[3
]}

Bonnomet, Arnaud ^{[1
,4
]}

Hunziker, Walter ^{[5
,6
]}

Noel, Agnes ^{[3
]}

Dormoy, Valerian ^{[1
]}

Nawrocki-Raby, Beatrice ^{[1
]}

Gilles, Christine ^{[3
]}

Polette, Myriam ^{[1
,7
]}

机构：

[1] Univ Reims, Inserm UMR S 1250, SFR CAP Sante, Reims, France

[2] Washington Univ, Dept Internal Med Med Oncol, St Louis, MO USA

[3] Univ Liege, Lab Tumor & Dev Biol, GIGA Canc, Liege, Belgium

[4] Univ Reims, Cellular & Tissue Imaging Platform, Reims, France

[5] Inst Mol & Cell Biol, Epithelial Cell Biol Lab, Singapore, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore

[7] CHU Reims, Pathol Lab, Reims, France

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

epithelial plasticity; ZO-1; epithelial-mesenchymal transition; immune infiltrate; tumor microenvironment; lung cancer; EPITHELIAL-MESENCHYMAL TRANSITION; ZONULA OCCLUDENS-1; BREAST-CANCER; TIGHT JUNCTIONS; EXPRESSION; MOLECULES; ANGIOGENESIS; INFLAMMATION; INVASION; CADHERIN;

D O I：

10.3389/fcell.2021.749364

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo, we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression.

引用

页数：9

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