ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer

被引：7

作者：

Neyrinck-Leglantier, Deborah ^{[1
]}

Lesage, Julien ^{[1
,2
]}

Blacher, Silvia ^{[3
]}

Bonnomet, Arnaud ^{[1
,4
]}

Hunziker, Walter ^{[5
,6
]}

Noel, Agnes ^{[3
]}

Dormoy, Valerian ^{[1
]}

Nawrocki-Raby, Beatrice ^{[1
]}

Gilles, Christine ^{[3
]}

Polette, Myriam ^{[1
,7
]}

机构：

[1] Univ Reims, Inserm UMR S 1250, SFR CAP Sante, Reims, France

[2] Washington Univ, Dept Internal Med Med Oncol, St Louis, MO USA

[3] Univ Liege, Lab Tumor & Dev Biol, GIGA Canc, Liege, Belgium

[4] Univ Reims, Cellular & Tissue Imaging Platform, Reims, France

[5] Inst Mol & Cell Biol, Epithelial Cell Biol Lab, Singapore, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore

[7] CHU Reims, Pathol Lab, Reims, France

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

epithelial plasticity; ZO-1; epithelial-mesenchymal transition; immune infiltrate; tumor microenvironment; lung cancer; EPITHELIAL-MESENCHYMAL TRANSITION; ZONULA OCCLUDENS-1; BREAST-CANCER; TIGHT JUNCTIONS; EXPRESSION; MOLECULES; ANGIOGENESIS; INFLAMMATION; INVASION; CADHERIN;

D O I：

10.3389/fcell.2021.749364

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro, we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo, we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression.

引用

页数：9

共 50 条

[1] Increased ZO-1 expression predicts valuable prognosis in non-small cell lung cancer
Ni, Songshi
Xu, Liqin
Huang, Jianfei
Feng, Jian
Zhu, Huijun
Wang, Gui
Wang, Xudong
[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2013, 6 (12): : 2887 - 2895
[2] Alterations of immune response of non-small cell lung cancer with Azacytidine
Wrangle, John
Wang, Wei
Koch, Alexander
Easwaran, Hariharan
Mohammad, Helai P.
Vendetti, Frank
VanCriekinge, Wim
De Meyer, Tim
Du, Zhengzong
Parsana, Princy
Rodgers, Kristen
Yen, Ray-Whay
Zahnow, Cynthia A.
Taube, Janis M.
Brahmer, Julie R.
Tykodi, Scott S.
Easton, Keith
Carvajal, Richard D.
Jones, Peter A.
Laird, Peter W.
Weisenberger, Daniel J.
Tsai, Salina
Juergens, Rosalyn A.
Topalian, Suzanne L.
Rudin, Charles M.
Brock, Malcolm V.
Pardoll, Drew
Baylin, Stephen B.
[J]. ONCOTARGET, 2013, 4 (11) : 2067 - 2079
[3] Neoadjuvant chemotherapy influence changes of the immune response in non-small cell lung carcinomas immune response in non-small cell lung carcinomas
Cuentas, Edwin Roger
Behrens, Carmen
Rodriguez-Canales, Jaime
Jiang, Mei
Pataer, Apar
Correa, Arelene
Swisher, Stephen
Sepesi, Boris
Weissferdt, Annikka
Kalhor, Neda
Zhang, Jiexin
Lee, Jack
Heymach, John
Moran, Cesar
Zhang, Jianjun
Gibbons, Don
Wistuba, Ignacio
[J]. CANCER RESEARCH, 2017, 77
[4] Prognostic Immune Markers in Non-Small Cell Lung Cancer-Response
Suzuki, Kei
Adusumilli, Prasad S.
[J]. CLINICAL CANCER RESEARCH, 2011, 17 (24) : 7836 - 7836
[5] Immune Signatures of Non-Small Cell Lung Cancer
Green, Susan
Dawe, David E.
Banerji, Shantanu
[J]. JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (06) : 913 - 915
[6] VCAM-1 induces signals that stimulate ZO-1 serine phosphorylation and reduces ZO-1 localization at lung endothelial cell junctions
Abdala-Valencia, Hiam
Kountz, Timothy S.
Marchese, Michelle E.
Cook-Mills, Joan M.
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2018, 104 (01) : 215 - 228
[7] Expression and localization of FOXO1 in non-small cell lung cancer
Maekawa, Takayo
Maniwa, Yoshimasa
Doi, Takefumi
Nishio, Wataru
Yoshimura, Masahiro
Ohbayashi, Chiho
Hayashi, Yoshitake
Okita, Yutaka
[J]. ONCOLOGY REPORTS, 2009, 22 (01) : 57 - 64
[8] Diversity and heterogeneity of immune states in non-small cell lung cancer and small cell lung cancer
Rice, Shawn J.
Belani, Chandra P.
[J]. PLOS ONE, 2021, 16 (12):
[9] Blood Biomarkers of Response to Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer
Alfranca, Yolanda Lage
Garcia, Maria Eugenia Olmedo
Rueda, Ana Gomez
Ballesteros, Pablo Alvarez
Rodriguez, Diana Rosero
Velasco, Marisa Torres
[J]. JOURNAL OF CLINICAL MEDICINE, 2022, 11 (11)
[10] Immune checkpoint blockade and biomarkers of clinical response in non-small cell lung cancer
Hallqvist, Andreas
Rohlin, Anna
Raghavan, Sukanya
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2020, 92 (06)

← 1 2 3 4 5 →