CORRELATION BETWEEN SERUM SUA LEVEL AND THYROID FUNCTION AND THYROID AUTOANTIBODY IN PATIENTS WITH HYPERTHYROIDISM

Objective: To investigate the correlation between serum uric acid (SUA) level and thyroid function and thyroid autoantibodies in patients with hyperthyroidism. Methods: In this study, 53 patients with hyperthyroidism who were treated in the endocrinology department of our hospital from July 2017 to March 2018 were randomly selected as the study group upon approval of the hospital ethics committee. At the same time, 55 healthy subjects were selected as the control group. Serum SUA, blood creatinine (Scr) and urea nitrogen (BUN) were detected by automatic biochemical analyser. The levels of free triiodothyrogenic acid (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-thyroid hormone receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb) and thyroid globulin antibody (TGAb) were detected by chemiluminescence. Pearson correlation test was used to analyse the correlation between serum SUA level and thyroid function and thyroid autoantibody in patients with hyperthyroidism. Results: Compared with the control group, the serum levels of SUA, Scr and BUN in the study group were significantly increased (P<0.01 or P<0.05). FT3 and FT4 levels in the study group were significantly higher than those in the control group, while TSH levels were significantly lower (P<0.01). Compared with the control group, TRAb and TPOAb levels in the study group were significantly increased and TGAb levels were significantly decreased (P<0.01). Pearson correlation test showed that serum SUA levels were positively correlated with Scr, BUN, FT3, FT4 and TRAb levels, and negatively correlated with TSH levels (P<0.05). However, the levels were not significantly correlated with TPOAb and TGAb (P>0.05). Conclusion: Serum levels of SUA, Scr and BUN in patients with hyperthyroidism were significantly higher than those in normal healthy patients, and the levels of thyroid function and thyroid autoantibody were also changed to varying degrees. Moreover, their expression levels were correlated to some extent.