D-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes

被引：12
|
作者：
Niibo, Misato [1 ,2 ]
Kanasaki, Akane [1 ]
Iida, Tetsuo [1 ]
Ohnishi, Keisuke [2 ]
Ozaki, Taro [2 ]
Akimitsu, Kazuya [3 ,4 ]
Minamino, Tetsuo [2 ]
机构：
[1] Matsutani Chem Ind Co Ltd, Res & Dev, Itami, Hyogo, Japan
[2] Kagawa Univ, Fac Med, Dept Cardiorenal & Cerebrovasc Med, Miki, Kagawa, Japan
[3] Kagawa Univ, Int Inst Rare Sugar Res, Miki, Kagawa, Japan
[4] Kagawa Univ, Fac Agr, Miki, Kagawa, Japan
来源：
PLOS ONE | 2022年 / 17卷 / 01期
关键词：
D-PSICOSE; MESSENGER-RNA; RARE SUGAR; METABOLISM; PREVENTION; EXPANSION; TOXICITY; DISEASE; SERICIN;
D O I：
10.1371/journal.pone.0263300
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
D-allulose is a rare sugar that has been reported to possess anti-hyperglycemic effects. In the present study, we hypothesized that D-allulose is effective in attenuating the progression of diabetic nephropathy in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat model of type 2 diabetes mellitus. Drinking water with or without 3% D-allulose was administered to OLETF rats for 13 weeks. Long-Evans Tokushima Otsuka rats that received drinking water without D-allulose were used as non-diabetic control rats. D-allulose significantly attenuated the increase in blood glucose levels and progressive mesangial expansion in the glomerulus, which is regarded as a characteristic of diabetic nephropathy, in OLETF rats. D-allulose also attenuated the significant increases in renal IL-6 and tumor necrosis factor-alpha mRNA levels in OLETF rats, which is a proinflammatory parameter. Additionally, we showed that D-allulose suppresses mesangial matrix expansion, but its correlation with suppressing renal inflammation in OLETF rats should be investigated further. Collectively, our results support the hypothesis that D-allulose can prevent diabetic nephropathy in rats.
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页数：12
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