Formation of all-carbon quaternary centers by copper-catalyzed asymmetric conjugate addition

被引：12
|
作者：
Alexakis, Alexandre [1 ]
Vuagnoux-d'Augustin, Magali [1 ]
Martin, David [1 ]
Kehrli, Stefan [1 ]
Palais, Laetitia [1 ]
Henon, Hne [1 ]
Hawner, Christine [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
来源：
CHIMIA | 2008年 / 62卷 / 06期
关键词：
aluminium; asymmetry; catalysis; conjugate addition; copper; magnesium; zinc;
D O I：
10.2533/chimia.2008.461
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This mini-review deals with a special, and challenging, aspect of the asymmetric conjugate addition: the formation of all-carbon quaternary centers by reaction with Michael acceptors bearing a polysubstituted unsaturation. Only copper catalysts allow this transformation, along with a careful choice of primary organometallics and chiral ligand. The resulting adducts are useful intermediates for the synthesis of more complex natural products.
引用
收藏
页码：461 / 464
页数：4
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