Formation of all-carbon quaternary centers by copper-catalyzed asymmetric conjugate addition

被引：12

作者：

Alexakis, Alexandre ^{[1
]}

Vuagnoux-d'Augustin, Magali ^{[1
]}

Martin, David ^{[1
]}

Kehrli, Stefan ^{[1
]}

Palais, Laetitia ^{[1
]}

Henon, Hne ^{[1
]}

Hawner, Christine ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

CHIMIA | 2008年 / 62卷 / 06期

关键词：

aluminium; asymmetry; catalysis; conjugate addition; copper; magnesium; zinc;

D O I：

10.2533/chimia.2008.461

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This mini-review deals with a special, and challenging, aspect of the asymmetric conjugate addition: the formation of all-carbon quaternary centers by reaction with Michael acceptors bearing a polysubstituted unsaturation. Only copper catalysts allow this transformation, along with a careful choice of primary organometallics and chiral ligand. The resulting adducts are useful intermediates for the synthesis of more complex natural products.

引用

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页码：461 / 464

页数：4

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